Systematic Review of CT and MR Perfusion Imaging for Assessment of Acute Cerebrovascular Disease

American Journal of Neuroradiology

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Fig 1.
Flowchart depicting our review of the literature.

Table 1.

Initial (abstract) and final (full-text) consensus Fryback level assignments

Fryback Level	Abstract Screen (no.)	Full-Text Review Consensus Reassignment	Change (no.)	Final (no.)
1	78	Not further reviewed	+6	84
2	37	5 excluded	+12	49
		1 reassigned to level 1
		6 reassigned to level 3
3	49	12 excluded	+9	58
		1 reassigned to level 1
		19 reassigned to level 2
		1 reassigned to level 4
4	2	Both reassigned to level 3	−1	1
5	28	2 excluded	−28	0
		5 reassigned to level 2
		21 reassigned to level 3
6	0	None	0	0
NA^*	25	8 excluded	−25	0
		4 assigned to level 1
		13 assigned to level 3

* Additional articles reviewed during final manuscript preparation; not initially assigned.

Table 2.

Categories used to classify articles according to degree of influence on decision making

Category
1	Perfusion used to guide treatment
2	Predict clinical outcome (suggestive evidence that PWI can help triage patients)
3	Predict final infarct size
4	Determine effects of therapy on perfusion abnormalities
5	Characterize infarct types or to better understand infarct-like processes
6	As a comparison with DWI but no outcome measure
7	Compare perfusion with an imaging technique other than MR
8	Solely as an entry criterion
9	Although perfusion data were recorded, analysis of perfusion data was not a goal of the study