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Research ArticleBRAIN

Noncontrast CT in Deep Cerebral Venous Thrombosis and Sinus Thrombosis: Comparison of its Diagnostic Value for Both Entities

J. Linn, T. Pfefferkorn, K. Ivanicova, S. Müller-Schunk, S. Hartz, M. Wiesmann, M. Dichgans and H. Brückmann
American Journal of Neuroradiology April 2009, 30 (4) 728-735; DOI: https://doi.org/10.3174/ajnr.A1451
J. Linn
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T. Pfefferkorn
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K. Ivanicova
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S. Müller-Schunk
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S. Hartz
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M. Wiesmann
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M. Dichgans
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H. Brückmann
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    Fig 1.

    Patient 5. A 31-year-old woman with combined deep cerebral venous thrombosis of the TSV, the ICVs, the BVR, the VG, the SS, and the LTS. A, The NCCT scan demonstrates an attenuated vein sign in both ICVs (thin arrows), in the SS (crossed arrow) as well as bilateral edema in the thalami and in the putamen (thick arrows). B, Multiplanar sagittal reconstruction of an MDCTA. The thrombosis is visualized indirectly by demonstration of contrast-filling defects in the ICVs (thin arrow) and the SS (crossed arrows). C, An axial proton-attenuation-weighted MR image (acquired as a dual-echo acquisition) also depicts the bilateral edema in the thalamus and the putamen as well as edema in the left caudate nucleus as hyperintense areas (dotted arrows). D, Diffusion-weighted image (b-value = 1000) and the apparent diffusion coefficient map (E) show a restriction of diffusion in the respective areas (dotted arrows).

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    Fig 2.

    Examples for true-positive, false-positive, and false-negative cord signs in the evaluation of sinus thrombosis. A, A 35-year-old woman with an SVT of the SSS and the RTS, who presented with headache and nausea. The NCCT scan shows a true-positive cord sign in the SSS (dotted arrow) and the RTS (arrows). The case of this patient was judged as positive with regard to the presence of a cord sign by all 3 readers. B, A 27-year-old woman in the control group, who initially presented with headache, but all other available imaging modalities showed no pathologic findings and clinical follow-up was uneventful. The RTS appeared hyperattenuated on NCCT (arrows). This finding was interpreted as a cord sign by all readers, resulting in the false-positive diagnosis of a SVT in this patient. C and D, A 45-year old woman with headache and nausea and a SVT involving the RTS and the SSS. The NCCT scan (C) shows no hyperattenuated signal intensity (ie, no cord sign) in the RTS or the SSS: The case of this patient was judged as false-negative regarding the presence of a cord sign by all readers. D, Multiplanar sagittal reconstruction of a MDCTA demonstrates contrast-filling defects in the RTS (arrow) and in the SSS (dotted arrow), indicating an SVT.

Tables

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    Table 1:

    Characteristics of patients with DVT

    Patient No.Age/SexDiagnosisAvailable ImagingAffected Venous StructuresParenchymal ChangesDiagnostic Delay (d)#
    139/fIDVTNCCT, MRI, MRARICV, SSEdema right thalamus, caudate nucleus, putamen11
    239/fIDVTNCCT, CTA, MRI, MRALTSV, both ICV, both BVR, VG, SSEdema thalami, caudate nuclei, putamen,  bilaterally14
    347/fIDVTNCCT, CTA, MRI, MRA,  DSAboth ICV, VG, SSHemorrhage left thalamus, edema both thalami21
    449/mIDVTNCCT, MRI, MRA, DSALTSV, both ICV, both BVR, VG, SSEdema both thalami1
    531/fCDVTNCCT, CTA, MRI, MRA,  DSABoth TSV, both ICV, both BVR, VG,  SS, LTSEdema both thalami, left caudate nucleus,  putamen, bilaterally1
    627/mIDVTNCCT, CTA, MRI, MRALTSV, both ICV, LBVR, VG, SSEdema both thalami, posterior part of left  hippocampus28
    741/fCDVTNCCT, CTA, MRI, MRABoth ICV, RBVR, VG, SS, RTSNone5
    838/fCDVTNCCT, CTA, MRI, MRABoth ICV, RBVR, VG, SS, LTS, LSS  SSSEdema both thalami, left parietal lobe, left  occipital lobe, hemorrhage both thalami6
    • Note:—DVT indicates deep cerebral venous thrombosis; f, female; m, male; IDVT, isolated deep venous thrombosis; CDVT, combined deep venous thrombosis; NCCT, noncontrast cranial CT; CTA, CT angiography; MRI, MR imaging; MRA, MR angiography; DSA, digital subtraction angiography; ICV, internal cerebral veins; RICV, right internal cerebral vein; SS, straight sinus; TSV, thalamostriate vein; LTSV, left thalamostriate vein; BVR, basal veins of Rosenthal; LBVR, left basal vein of Rosenthal; RBVR, right basal vein of Rosenthal; VG, great vein of Galen; diagnostic delay #, time between onset of initial symptoms and definite diagnosis of DVT; LTS, left transverse sinus; RTS, right transverse sinus; LSS, left sigmoid sinus; SSS, superor sagittal sinus.

    • View popup
    Table 2:

    Characteristics of patients with SVT

    Patient No.Age/SexAvailable ImagingAffected SinusesParenchymal ChangesDiagnostic Delay (d)#
    137/fNCCT, CTA, MRI, MRASSS, LTS, LSSNone7
    245/fNCCT, CTASSS, RTSNone5
    327/fNCCT, CTA, MRI, MRASSSNone3
    444/fNCCT, MRI, MRA, DSASSS, LTS, LSSNone1
    535/fNCCT, CTA, MRI, MRASSS, RTSNone4
    663/mNCCT, CTA, MRI, MRASSS, RTSEdema and hemorrhage, right occipital lobe2
    723/fNCCT, CTA, MRI, MRASSS, RSS, CVEdema and hemorrhage, right frontal lobe1
    878/fNCCT, CTA, MRI, MRALTSEdema, left frontal lobe1
    943/fNCCT, MRI, MRA, DSASSS, LTS, LSS, CVEdema and hemorrhage, right parietal lobe3
    1052/mNCCT, CTA, MRI, MRA, DSASSS, RTSEdema and hemorrhage, right parietal lobe1
    1123/fNCCT, CTA, MRI, MRALTS, LSS, RSSEdema, left parietal and temporal lobes2
    1230/fNCCT, CTA, MRI, MRA, DSASSS, LTS, LSSEdema and hemorrhage, left occipital lobe2
    1320/fNCCT, MRI, MRA, DSASSS, RTS, RSSNone6
    1421/mNCCT, CTA, MRI, MRALTS, RTSNone2
    1582/fNCCT, CTA, MRI, MRASSS, RTS, CVEdema and hemorrhage, left frontal and occipital lobes0
    1664/fNCCT, CTASSS, LTS, LSSEdema, left parietal lobe2
    1722/fNCCT, CTA, MRI, MRALTS, LSSNone8
    1852/mNCCT, MRI, MRA, DSASSS, LTS, LSSEdema and hemorrhage, right parietal lobe1
    1966/mNCCT, MRI, MRASSS, LTS, LSSEdema, left frontal lobe0
    2053/fNCCT, CTA, MRI, MRALSSNone5
    2160/fNCCT, CTA, MRI, MRASSS, LTS, CVNone3
    2233/mNCCT, CTA, MRI, MRALTS, LSSNone3
    2365/fNCCT, CTA, MRI, MRALTS, LSSEdema and hemorrhage, left occipital lobe1
    2432/fNCCT, CTA, MRI, MRASSSEdema and hemorrhage, right frontal lobe2
    2518/mNCCT, MRI, MRA, DSASSS, LTS, LSSEdema and hemorrhage, right frontal lobe0
    • Note:—SVT indicates sinus thrombosis; RSS, right sigmoid sinus; CV, cortical veins.

    • View popup
    Table 3:

    Available imaging modalities*

    Patient GroupTotalMRI, DSA, MDCTAMRI, DSAMRI, MDCTAMRI aloneMDCTA alone
    DVT8 (100)2 (25)1 (12.5)4 (50)1 (12.5)0 (0)
    SVT25 (100)2 (8)5 (20)15 (60)1 (4)2 (8)
    Control36 (100)0 (0)5 (13.9)9 (25)5 (13.9)17 (47.2)
    Total69 (100)4 (5.8)11 (15.9)28 (40.6)7 (10.1)19 (27.5)
    • Note:—MRI indicates magnetic resonance imaging including venous MR angiography and T2*-weighted images; DSA, digital subtraction angiography; MDCTA, multi-detector row CT angiography; DVT, deep venous thrombosis; SVT, sinus thrombosis.

    • * Data are given as numbers (percentages).

    • View popup
    Table 4:

    Results of the readings–veins

    Venous StructureBlinded ReadingsConsensus ReadingIntraobserver Agreement (κ values)Sensitivity (95% CI)*Specificity (95% CI)*
    Dense Vein Signtpfptnfn
    SS2423118510.9695.8 (85.6–98.9)99.5 (98.1–99.9)
    LICV1918118230.9285.7 (72.7–89.6)99.5 (98–99.9)
    RICV2423118210.9695.8 (85.6–98.9)99.5 (98.1–99.8)
    VG2423118210.9695.8 (85.6–98.9)99.5 (98.1–99.8)
    LBVR1111019510.9891.7 (74.9–91.7)100 (99–100)
    RBVR1414019210.9893.3 (79.6–93.3)100 (98.9–100)
    LTSV1312119400.98100 (83–100)99.5 (98.4–99.5)
    RTSV95419710.9083.3 (47.6–96.9)98 (96.9–98.4)
    Total1381299150990.95893.5 (89.9–95.9)99.4 (99.1–99.6)
    • Note:—tp indicates true-positive; fp, false-positive; tn, true-negative; fn, false-negative; 95% CI, 95% confidence interval; LICV, left internal cerebral vein; RTSV, right thalamostriate vein.

    • * Data are given in percentages.

    • View popup
    Table 5:

    Results of the readings–sinus

    SinusBlinded ReadingConsensus ReadingInterobserver Agreement (κ values)Sensitivity (95% CI)*Specificity (95% CI)*
    Cord Signtpfptnfn
    SSS45369138240.7060 (51.4–66.3)93.9 (90.4–96.4)
    ISS80819630.840 (0–53.3)96.1 (96.1–96.9)
    LTS18117146430.7620.4 (13.3–26.4)95.4 (92.9–97.5)
    RTS20812171160.833.3 (19.3–48.4)93.4 (91.6–95.4)
    LSS1477164290.7819.4 (10.8–28.1)95.9 (94.1–97.7)
    RSS1111018880.8411.1 (2–39.1)94.9 (94.5–96.2)
    Total116635310031230.8033.9 (28.8–38.8)95 (94.1–95.8)
    • Note:—ISS indicates inferior sagittal sinus.

    • * Data are given in percentages.

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J. Linn, T. Pfefferkorn, K. Ivanicova, S. Müller-Schunk, S. Hartz, M. Wiesmann, M. Dichgans, H. Brückmann
Noncontrast CT in Deep Cerebral Venous Thrombosis and Sinus Thrombosis: Comparison of its Diagnostic Value for Both Entities
American Journal of Neuroradiology Apr 2009, 30 (4) 728-735; DOI: 10.3174/ajnr.A1451

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Noncontrast CT in Deep Cerebral Venous Thrombosis and Sinus Thrombosis: Comparison of its Diagnostic Value for Both Entities
J. Linn, T. Pfefferkorn, K. Ivanicova, S. Müller-Schunk, S. Hartz, M. Wiesmann, M. Dichgans, H. Brückmann
American Journal of Neuroradiology Apr 2009, 30 (4) 728-735; DOI: 10.3174/ajnr.A1451
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