Abstract
BACKGROUND AND PURPOSE: LA is a condition caused by chronic cerebral ischemia and it represents an independent risk for stroke. The purpose of this work was to determine whether CAWT studied by using MDCTA is correlated with LA and its severity.
MATERIALS AND METHODS: Ninety-eight patients ≥60 years of age were retrospectively studied by using multidetector row CT. Supra-aortic vessel analysis and brain CT were performed in the same procedure. In each patient, CAWT was measured with an internal digital caliper, and the presence and severity of LA were assessed. Correlation coefficients by using Spearman statistics and ROC curves were calculated. A P value < .05 was considered statistically significant.
RESULTS: Measurements of the distal common CAWT ranged from 0.5 to 1.53 mm. A correlation between LA and increased CAWT was observed (Pearson correlation, 0.33; P < .001). On the basis of a threshold of 0.9 mm, an important statistical association between increased CAWT and LA (P < .0001) was found. With the same threshold, ROC curve analysis indicated a sensitivity of 55% and a specificity of 75% for LA.
CONCLUSIONS: The results of this study show a statistically significant correlation between increased CAWT and LA (and its severity).
Abbreviations
- CAD
- coronary artery disease
- CAWT
- carotid artery wall thickness
- CD-US
- color Doppler ultra-sonography
- CI
- confidence interval
- CTA
- CT angiography
- ICA
- internal carotid artery
- IMT
- intima-media thickness
- LA
- leukoaraiosis
- LR
- likelihood ratio
- MDCTA
- multidetector-row CT angiography
- OR
- odds ratio
- ROC
- receiver operating characteristic analysis
- SE
- standard error
- TIA
- transient ischemic attack
- US
- ultra-sonography
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