Abstract
SUMMARY: Perfusion imaging of brain tumors has been performed by using various tracer and nontracer modalities and can provide additional physiologic and hemodynamic information, which is not available with routine morphologic imaging. Tumor vascular perfusion parameters obtained by using CT or MR perfusion have been used for tumor grading, prognosis, and treatment response in addition to differentiating treatment/radiation effects and non-neoplastic lesions from neoplasms. This article is an overview of the utility of PCT for assessment of brain tumors and describes the technique, its advantages, and limitations.
Abbreviations
- BBB
- blood-brain barrier
- CBF
- cerebral blood flow
- CBV
- cerebral blood volume
- DSC
- dynamic susceptibility contrast
- FDG-PET
- fluorodeoxyglucose–positron-emission tomography
- Ktrans
- volume transfer coefficient
- MRI
- MR imaging
- MTT
- mean transit time
- MVCP
- microvascular cellular proliferation
- MVD
- microvascular density
- PCT
- perfusion CT
- PS
- permeability surface-area product
- rCBV
- regional cerebral blood flow
- ROI
- region of interest
- rPSR
- relative percentage signal recovery
- SDF-1
- stromal derived factor-1
- TDL
- tumefactive demyelinating lesion
- TVA
- total vascular area
- VEGF
- vascular endothelial growth factor
- WHO
- World Health Organization
- © 2011 by American Journal of Neuroradiology
Indicates open access to non-subscribers at www.ajnr.org
In this issue
Jump to section
- Article
- Abstract
- Abbreviations
- In Vivo Perfusion Imaging versus Histopathology
- Perfusion Parameters and Their Importance
- PCT Technique
- Relationship between Glioma Grade and PCT Parameters
- Heterogeneity of Glioma Angiogenesis and Perfusion Imaging
- Role of PCT in Differentiating Recurrent Tumor from Radiation Necrosis
- Differentiating Gliomas from Other Non-Neoplastic Lesions and from Lymphomas
- Advantages and Limitations of PCT for Brain Tumor Assessment
- Conclusions
- References
- Figures & Data
- Info & Metrics
- Responses
- References
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