Index by author

Hemodyalisis may not prevent brain damage resulting from accumulation of urea and other metabolites as previously believed. These investigators used voxelwise DTI to assess the white matter of 28 patients with end-stage renal disease. All DTI parameters were abnormal, especially in the callosum, sagittal stratum, and pons.

This article reviews the MRI and clinical findings in 70 spinal cord metastases; 20% of patients had multiple metastases and 8% were asymptomatic. Spinal cord metastases were the initial clinical presentation in 20% of patients. Nearly all metastases showed contrast enhancement and had extensive edema. Cysts and hemorrhage were, however, uncommon and nearly 60% of patients had other metastases to the CNS or that were seen in studies in other organs. Accompanying pial metastases were also common.

These authors used MR imaging studies from 210 patients being treated with bapineuzumab derived from 3 phase-2 studies to assess imaging abnormalities related to amyloidosis. Areas of edema and exudate/effusions were seen in 17% and hemosiderin deposition in 12%. Of those with significant hemosiderin deposition, nearly all had microhemorrhages and almost 50% of those with edema and exudate had hemosiderosis.