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Index by author

March 01, 2013; Volume 34,Issue 3

  1. Cloughesy, T.F.

    1. EDITOR'S CHOICEBrain
      Probabilistic Radiographic Atlas of Glioblastoma Phenotypes
      B.M. Ellingson, A. Lai, R.J. Harris, J.M. Selfridge, W.H. Yong, K. Das, W.B. Pope, P.L. Nghiemphu, H.V. Vinters, L.M. Liau, P.S. Mischel and T.F. Cloughesy
      American Journal of Neuroradiology March 2013, 34 (3) 533-540; DOI: https://doi.org/10.3174/ajnr.A3253

      Images from over 500 patients with glioblastoma were used to build location atlases corresponding to genetic and biologic abnormalities as well as prognosis based on age. Most glioblastomas grew into the periventricular regions adjacent to the subventricular zone. MGMT promoter methylated tumors occurred more frequently in the left temporal lobe in young patients, in IDH1 mutant tumors, in those having the proneural gene expression subtype, and in tumors lacking loss of PTEN that occurred most frequently in the frontal lobe. MGMT methylated tumors with IDH1 mutation tended to occur in the left frontal lobe. EGFR amplified and EGFR variant 3-expressing tumors were found most frequently in the left temporal lobe. Tumors in the left temporal lobe were associated with favorable response to radiochemotherapy and increased survival.

  2. Corso, P.J.

    1. EDITOR'S CHOICEBrain
      Open Access
      Blood-Brain Barrier Disruption after Cardiac Surgery
      J.G. Merino, L.L. Latour, A. Tso, K.Y. Lee, D.W. Kang, L.A. Davis, R.M. Lazar, K.A. Horvath, P.J. Corso and S. Warach
      American Journal of Neuroradiology March 2013, 34 (3) 518-523; DOI: https://doi.org/10.3174/ajnr.A3251

      To shed light on brain complications occurring after heart surgery, the authors assessed BBB disruption and DWI findings in half of their patients by imaging at 24 hours after surgery and 24–48 hours later. Additionally, postcontrast T1 images were obtained postoperatively at 2–4 days in the other half of the patients. Almost half the patients undergoing cardiac surgery had evidence of BBB abnormalities and three-quarters showed acute lesions on DWI after surgery. BBB disruption is more prevalent in the first 24 hours after surgery. These findings suggest that MR can be used as an imaging biomarker to assess therapies that may protect the BBB in patients undergoing heart surgery.

  3. Costalat, V.

    1. FELLOWS' JOURNAL CLUBNeurointervention
      Evaluation of an Intravenous-Endovascular Strategy in Patients with Acute Proximal Middle Cerebral Artery Occlusion
      J.-F. Vendrell, R. Mernes, N. Nagot, D. Milhaud, K. Lobotesis, V. Costalat, P. Machi, I.L. Maldonado, C. Riquelme, C. Arquizan and A. Bonafe
      American Journal of Neuroradiology March 2013, 34 (3) 603-608; DOI: https://doi.org/10.3174/ajnr.A3230

      Here, the safety and efficacy of mechanical thrombectomy after intravenous therapy failure were assessed in 123 patients with acute MCA occlusions. All patients imaged were within 4.5 hours of onset, had DWI ASPECTS greater than 5, and variable NIHSS scores (8–25). The authors found that mechanical thrombectomy after failure of intravenous thrombolysis improves clinical outcomes at 3 months and could represent an alternative in the management of patients with acute MCA occlusion. Additionally, no symptomatic intracranial hemorrhages were detected in patients treated this way, suggesting this protocol is safe.

  4. Crobeddu, E.

    1. Review Articles
      Open Access
      Review of 2 Decades of Aneurysm-Recurrence Literature, Part 2: Managing Recurrence after Endovascular Coiling
      E. Crobeddu, G. Lanzino, D.F. Kallmes and H.J. Cloft
      American Journal of Neuroradiology March 2013, 34 (3) 481-485; DOI: https://doi.org/10.3174/ajnr.A2958
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