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American Journal of Neuroradiology

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Index by author

November 01, 2015; Volume 36,Issue 11

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Sung, Y.H.
1. EDITOR'S CHOICEAdult Brain
  
  Open Access
  Nigrosome 1 Detection at 3T MRI for the Diagnosis of Early-Stage Idiopathic Parkinson Disease: Assessment of Diagnostic Accuracy and Agreement on Imaging Asymmetry and Clinical Laterality
  Y. Noh, Y.H. Sung, J. Lee and E.Y. Kim
  
  American Journal of Neuroradiology November 2015, 36 (11) 2010-2016; DOI: https://doi.org/10.3174/ajnr.A4412
  
  Nigrosomes are calbindin-poor zones within the substantia nigra pars compacta, and are the primary subregion where dopaminergic cells are lost in Parkinson disease. High-resolution 3D multiecho imaging was performed at 3T in 13 healthy subjects and 24 patients with idiopathic Parkinson disease confirmed by ¹⁸F-FP-CIT PET. Diagnostic sensitivity, specificity, and accuracy of the nigrosome 1 detection at 3T MR imaging was 100%, 84.6%, and 94.6%, respectively. Further, the clinical laterality was in high concordance with the laterality of the nigrosome 1 detection.

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