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Relative CBV estimates were calculated from dynamic susceptibility contrast MR imaging in double-baseline examinations of 33 patients with treatment-naïve and pathologically proved glioblastoma multiforme. Normalized and standardized relative CBV were calculated by using 6 common postprocessing methods. The ΔR2* estimation method that incorporates leakage correction offers the best repeatability for rCBV, with standardized rCBV being less variable.

The authors performed a crossover, intraindividual comparison of 0.1-mmol/kg gadobenate with 0.1-mmol/kg gadoterate (Arm 1) and 0.05-mmol/kg gadobenate with 0.1-mmol/kg gadoterate (Arm 2). In Arm 1, a significant superiority of 0.1-mmol/kg gadobenate was demonstrated by all readers for all end points. In Arm 2, no significant differences were observed for any reader and any end point, with the exception of percentage enhancement for reader 2 in favor of 0.05-mmol/kg gadobenate.