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The authors explored regions of diffusion restriction following bevacizumab therapy in patients with glioblastoma by 1) analyzing tissue samples from patients at postmortem to pathologically confirm tumor cellularity or coagulative necrosis and 2) assessing the patient populationto determine the effect that these lesions have on overall survival. The postmortem examinations were performed on 6 patients with recurrent glioblastoma on bevacizumab withprogressively growing regions of diffusion restriction. ADC values were extracted from regions of both hypercellular tumor and necrosis. They conclude that progressive diffusion-restricted lesions were pathologically confirmed to be coagulative necrosis surrounded by viable tumor and associated with decreased overall survival.

Thirty-seven patients who had undergone both high-resolution MR imaging and DSA for intracranial artery disease were evaluated. The degree of stenosis and the minimal luminal diameter were independently measured by 2 observers on both DSA and high-resolution MR imaging, and the results were compared. The 2 observers independently diagnosed intracranial artery diseases on DSA and high-resolution MR imaging. High-resolution MR imaging showed moderate-to-excellent agreement and significant correlations with DSA on the degree of stenosis and minimal luminal diameter. The authors conclude that high-resolution MR imaging may be an imaging method comparable with DSA for the characterization and diagnosis ofvarious intracranial artery diseases.