Advertisement

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleAdult Brain
Open Access

Mitotic Activity in Glioblastoma Correlates with Estimated Extravascular Extracellular Space Derived from Dynamic Contrast-Enhanced MR Imaging

S.J. Mills, D. du Plessis, P. Pal, G. Thompson, G. Buonacorrsi, C. Soh, G.J.M. Parker and A. Jackson
American Journal of Neuroradiology May 2016, 37 (5) 811-817; DOI: https://doi.org/10.3174/ajnr.A4623

Article Figures & Data

Figures

  • Fig 1.
    Fig 1.

    A, Boxplot of fibrillar histology and ve (estimated P = .007). Sample histologic specimens showing tumors without (B) and with (C) the presence of fibrils (small fibers measuring approximately 1 mm, black arrows, C). H&E stain ×40 magnification. D, Boxplot of frank necrosis and Ktrans (estimated P = .005).

  • Fig 2.
    Fig 2.

    Scatterplot of mitotic activity versus ve (P = .012, ρ = 0.470), marker shapes depict separate scores of cell density measures.

Tables

  • Table 1:

    Cross-correlations of MRI parametersa

    Untreated GBM (n = 28)
    vevpEnFIAUC60>0EnFIAUC60>2.5
    Ktrans0.016,b ρ = 0.4500.006,c ρ = 0.5070.005,c ρ = 0.513<0.001,c ρ = 0.784
    ve0.105, ρ = 0.3130.888, ρ = 0.0280.059, ρ = 0.361
    vp0.02,b ρ = 0.437<0.001,c ρ = 0.620
    EnFIAUC60>0<0.001,c ρ = 0.825

    • ↵a Significance levels and Spearman ρ are shown.

    • ↵b Significance was P < .05.

    • ↵c Significance was P < .01.

  • Table 2:

    Cross-correlations of quantitative histologic measuresa

    Untreated GBM (n = 28)
    ESA RatioVSA RatioVPC/mm2
    Mitotic activity0.098, ρ = 0.3250.066, ρ = 0.3580.737, ρ = 0.068
    ESA ratio<0.001,b ρ = 0.9930.04,c ρ = 0.530
    VSA ratio0.04,c ρ = 0.532

    • Note:—VPC indicates vascular profile count per square millimeter; VSA, vascular surface area; ESA, endothelial surface area.

    • ↵a Significance levels and Spearman ρ are shown.

    • ↵b Significance was P < .01.

    • ↵c Significance was P < .05.

Back to top

In this issue

Advertisement
Print
Download PDF
Email Article
Cite this article
0 Responses
Respond to this article
Bookmark this article
Mitotic Activity in Glioblastoma Correlates with Estimated Extravascular Extracellular Space Derived from Dynamic Contrast-Enhanced MR Imaging
S.J. Mills, D. du Plessis, P. Pal, G. Thompson, G. Buonacorrsi, C. Soh, G.J.M. Parker, A. Jackson
American Journal of Neuroradiology May 2016, 37 (5) 811-817; DOI: 10.3174/ajnr.A4623
del.icio.us logo Twitter logo Facebook logo Mendeley logo
Purchase

Jump to section

Related Articles

Cited By...

  • No citing articles found.

More in this TOC Section

Similar Articles

Advertisement