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Research ArticleAdult Brain

Engorgement of Deep Medullary Veins in Neurosarcoidosis: A Common-Yet-Underrecognized Cerebrovascular Finding on SWI

C. Zamora, S.-C. Hung, C. Tomingas, C. Atkinson and M. Castillo
American Journal of Neuroradiology November 2018, 39 (11) 2045-2050; DOI: https://doi.org/10.3174/ajnr.A5783
C. Zamora
aFrom the Division of Neuroradiology, Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
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S.-C. Hung
aFrom the Division of Neuroradiology, Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
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C. Tomingas
aFrom the Division of Neuroradiology, Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
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C. Atkinson
aFrom the Division of Neuroradiology, Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
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M. Castillo
aFrom the Division of Neuroradiology, Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
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References

  1. 1.↵
    1. Sakthivel P,
    2. Bruder D
    . Mechanism of granuloma formation in sarcoidosis. Curr Opin Hematol 2017;24:59–65 doi:10.1097/MOH.0000000000000301 pmid:27755127
    CrossRefPubMed
  2. 2.↵
    1. Smith JK,
    2. Matheus MG,
    3. Castillo M
    . Imaging manifestations of neurosarcoidosis. AJR Am J Roentgenol 2004;182:289–95 doi:10.2214/ajr.182.2.1820289 pmid:14736648
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Joubert B,
    2. Chapelon-Abric C,
    3. Biard L, et al
    . Association of prognostic factors and immunosuppressive treatment with long-term outcomes in neurosarcoidosis. JAMA Neurol 2017;74:1336–44 doi:10.1001/jamaneurol.2017.2492 pmid:29052709
    CrossRefPubMed
  4. 4.↵
    1. Fritz D,
    2. Voortman M,
    3. van de Beek D, et al
    . Many faces of neurosarcoidosis: from chronic meningitis to myelopathy. Curr Opin Pulm Med 2017;23:439–46 doi:10.1097/MCP.0000000000000401 pmid:28598872
    CrossRefPubMed
  5. 5.↵
    1. Bathla G,
    2. Watal P,
    3. Gupta S, et al
    . Cerebrovascular manifestations of neurosarcoidosis: an underrecognized aspect of the imaging spectrum. AJNR Am J Neuroradiol 2018;39:1194–1200 doi:10.3174/ajnr.A5492 pmid:29284603
    Abstract/FREE Full Text
  6. 6.↵
    1. van Rooijen JM,
    2. Mijnhout GS,
    3. Aalders TT, et al
    . Hydrocephalus, a rare manifestation of sarcoidosis. Clin Pract 2011;1:e66 doi:10.4081/cp.2011.e66 pmid:24765327
    CrossRefPubMed
  7. 7.↵
    1. Travers F,
    2. Maltête D,
    3. Morisse-Pradier H, et al
    . Intracranial hemorrhage in neurosarcoidosis. J Neurol Sci 2014;341:185–86 doi:10.1016/j.jns.2014.03.052 pmid:24735739
    CrossRefPubMed
  8. 8.↵
    1. Libman RB,
    2. Sharfstein S,
    3. Harrington W, et al
    . Recurrent intracerebral hemorrhage from sarcoid angiitis. J Stroke Cerebrovasc Dis 1997;6:373–75 doi:10.1016/S1052-3057(97)80222-4 pmid:17895037
    CrossRefPubMed
  9. 9.↵
    1. Zajicek JP,
    2. Scolding NJ,
    3. Foster O, et al
    . Central nervous system sarcoidosis: diagnosis and management. QJM 1999;92:103–17 doi:10.1093/qjmed/92.2.103 pmid:10209662
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Cohen Aubart F,
    2. Bouvry D,
    3. Galanaud D, et al
    . Long-term outcomes of refractory neurosarcoidosis treated with infliximab. J Neurol 2017;264:891–97 doi:10.1007/s00415-017-8444-9 pmid:28260120
    CrossRefPubMed
  11. 11.↵
    1. Liang L,
    2. Korogi Y,
    3. Sugahara T, et al
    . Evaluation of the intracranial dural sinuses with a 3D contrast-enhanced MP-RAGE sequence: prospective comparison with 2D-TOF MR venography and digital subtraction angiography. AJNR Am J Neuroradiol 2001;22:481–92 pmid:11237970
    Abstract/FREE Full Text
  12. 12.↵
    1. Taoka T,
    2. Fukusumi A,
    3. Miyasaka T, et al
    . Structure of the medullary veins of the cerebral hemisphere and related disorders. Radiographics 2017;37:281–97 doi:10.1148/rg.2017160061 pmid:28076020
    CrossRefPubMed
  13. 13.↵
    1. Hooshmand I,
    2. Rosenbaum AE,
    3. Stein RL
    . Radiographic anatomy of normal cerebral deep medullary veins: criteria for distinguishing them from their abnormal counterparts. Neuroradiology 1974;7:75–84 doi:10.1007/BF00341874 pmid:4369105
    CrossRefPubMedWeb of Science
  14. 14.↵
    1. Reichenbach JR,
    2. Venkatesan R,
    3. Schillinger DJ, et al
    . Small vessels in the human brain: MR venography with deoxyhemoglobin as an intrinsic contrast agent. Radiology 1997;204:272–77 doi:10.1148/radiology.204.1.9205259 pmid:9205259
    CrossRefPubMedWeb of Science
  15. 15.↵
    1. Vogl TJ,
    2. Bergman C,
    3. Villringer A, et al
    . Dural sinus thrombosis: value of venous MR angiography for diagnosis and follow-up. AJR Am J Roentgenol 1994;162:1191–98 doi:10.2214/ajr.162.5.8166009 pmid:8166009
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Crombé D,
    2. Haven F,
    3. Gille M
    . Isolated deep cerebral venous thrombosis diagnosed on CT and MR imaging: a case study and literature review. JBR-BTR 2003;86:257–61 pmid:14651078
    PubMed
  17. 17.↵
    1. D'Amore A,
    2. Conte G,
    3. Viglianesi A, et al
    . Elderly patient with dural sinus thrombosis leading to abnormal medullary veins and cerebral venous infarctions. Radiol Case Rep 2012;7:655 doi:10.2484/rcr.v7i2.655 pmid:27326284
    CrossRefPubMed
  18. 18.↵
    1. Mittal S,
    2. Wu Z,
    3. Neelavalli J, et al
    . Susceptibility-weighted imaging: technical aspects and clinical applications, Part 2. AJNR Am J Neuroradiol 2009;30:232–52 doi:10.3174/ajnr.A1461 pmid:19131406
    Abstract/FREE Full Text
  19. 19.↵
    1. Mirfakhraee M,
    2. Crofford MJ,
    3. Guinto FC Jr., et al
    . Virchow-Robin space: a path of spread in neurosarcoidosis. Radiology 1986;158:715–20 doi:10.1148/radiology.158.3.3945745 pmid:3945745
    CrossRefPubMedWeb of Science
  20. 20.↵
    1. Louveau A,
    2. Plog BA,
    3. Antila S, et al
    . Understanding the functions and relationships of the glymphatic system and meningeal lymphatics. J Clin Invest 2017;127:3210–19 doi:10.1172/JCI90603 pmid:28862640
    CrossRefPubMed
  21. 21.↵
    1. Louveau A,
    2. Smirnov I,
    3. Keyes TJ, et al
    . Structural and functional features of central nervous system lymphatic vessels. Nature 2015;523:337–41 doi:10.1038/nature14432 pmid:26030524
    CrossRefPubMed
  22. 22.↵
    1. Iliff JJ,
    2. Nedergaard M
    . Is there a cerebral lymphatic system? Stroke 2013;44:S93–95 doi:10.1161/STROKEAHA.112.678698 pmid:23709744
    FREE Full Text
  23. 23.↵
    1. Iliff JJ,
    2. Wang M,
    3. Liao Y, et al
    . A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med 2012;4:147ra111 doi:10.1126/scitranslmed.3003748 pmid:22896675
    Abstract/FREE Full Text
  24. 24.↵
    1. Engelhardt B,
    2. Carare RO,
    3. Bechmann I, et al
    . Vascular, glial, and lymphatic immune gateways of the central nervous system. Acta Neuropathol 2016;132:317–38 doi:10.1007/s00401-016-1606-5 pmid:27522506
    CrossRefPubMed
  25. 25.↵
    1. Albargothy NJ,
    2. Johnston DA,
    3. MacGregor-Sharp M, et al
    . Convective influx/glymphatic system: tracers injected into the CSF enter and leave the brain along separate periarterial basement membrane pathways. Acta Neuropathol 2018 May 12. [Epub ahead of print] doi:10.1007/s00401-018-1862-7 pmid:29754206
    CrossRefPubMed
  26. 26.↵
    1. Bacyinski A,
    2. Xu M,
    3. Wang W, et al
    . The paravascular pathway for brain waste clearance: current understanding, significance and controversy. Front Neuroanat 2017;11:101 doi:10.3389/fnana.2017.00101 pmid:29163074
    CrossRefPubMed
  27. 27.↵
    1. Brown MM,
    2. Thompson AJ,
    3. Wedzicha JA, et al
    . Sarcoidosis presenting with stroke. Stroke 1989;20:400–05 doi:10.1161/01.STR.20.3.400 pmid:2922780
    Abstract/FREE Full Text
  28. 28.↵
    1. Mochizuki I,
    2. Kubo K,
    3. Hond T
    . Widespread heavy damage of capillary endothelial cells in the pathogenesis of sarcoidosis: evidence by monoclonal von Willebrand factor immunohistochemistry in the bronchus and lung of patients with sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis 2014;31:182–90 pmid:25363217
    CrossRefPubMed
  29. 29.↵
    1. Hassan AS,
    2. Trobe JD,
    3. McKeever PE, et al
    . Linear magnetic resonance enhancement and optic neuropathy in primary angiitis of the central nervous system. J Neuroophthalmol 2003;23:127–31 doi:10.1097/00041327-200306000-00004 pmid:12782924
    CrossRefPubMed
  30. 30.↵
    1. Ganta K,
    2. Malik AM,
    3. Wood JB, et al
    . Radial contrast enhancement on brain magnetic resonance imaging diagnostic of primary angiitis of the central nervous system: a case report and review of the literature. J Med Case Rep 2014;8:26 doi:10.1186/1752-1947-8-26 pmid:24468474
    CrossRefPubMed
  31. 31.↵
    1. Yu X,
    2. Yuan L,
    3. Jackson A, et al
    . Prominence of medullary veins on susceptibility-weighted images provides prognostic information in patients with subacute stroke. AJNR Am J Neuroradiol 2016;37:423–29 doi:10.3174/ajnr.A4541 pmid:26514606
    Abstract/FREE Full Text
  32. 32.↵
    1. Mucke J,
    2. Möhlenbruch M,
    3. Kickingereder P, et al
    . Asymmetry of deep medullary veins on susceptibility weighted MRI in patients with acute MCA stroke is associated with poor outcome. PLoS One 2015;10:e0120801 doi:10.1371/journal.pone.0120801 pmid:25849958
    CrossRefPubMed
  33. 33.↵
    1. Terasawa Y,
    2. Yamamoto N,
    3. Morigaki R, et al
    . Brush sign on 3-T T2*-weighted MRI as a potential predictor of hemorrhagic transformation after tissue plasminogen activator therapy. Stroke 2014;45:274–76 doi:10.1161/STROKEAHA.113.002640 pmid:24172577
    Abstract/FREE Full Text
  34. 34.↵
    1. Hermier M,
    2. Nighoghossian N,
    3. Derex L, et al
    . Hypointense transcerebral veins at T2*-weighted MRI: a marker of hemorrhagic transformation risk in patients treated with intravenous tissue plasminogen activator. J Cereb Blood Flow Metab 2003;23:1362–70 doi:10.1097/01.WCB.0000091764.61714.79 pmid:14600444
    CrossRefPubMed
  35. 35.↵
    1. Horie N,
    2. Morikawa M,
    3. Nozaki A, et al
    . “Brush sign” on susceptibility-weighted MR imaging indicates the severity of moyamoya disease. AJNR Am J Neuroradiol 2011;32:1697–702 doi:10.3174/ajnr.A2568 pmid:21799039
    Abstract/FREE Full Text
  36. 36.↵
    1. O'Dwyer JP,
    2. Al-Moyeed BA,
    3. Farrell MA, et al
    . Neurosarcoidosis-related intracranial haemorrhage: three new cases and a systematic review of the literature. Eur J Neurol 2013;20:71–78 doi:10.1111/j.1468-1331.2012.03783.x pmid:22681045
    CrossRefPubMed
  37. 37.↵
    1. Krumholz A,
    2. Stern BJ
    . Neurologic manifestations of sarcoidosis. Handb Clin Neurol 2014;119:305–33 doi:10.1016/B978-0-7020-4086-3.00021-7 pmid:24365304
    CrossRefPubMed
  38. 38.↵
    1. Nozaki K,
    2. Judson MA
    . Neurosarcoidosis. Curr Treat Options Neurol 2013:15:492–504 doi:10.1007/s11940-013-0242-9 pmid:23703311
    CrossRefPubMed
  39. 39.↵
    1. Ginat DT,
    2. Dhillon G,
    3. Almast J
    . Magnetic resonance imaging of neurosarcoidosis. J Clin Imaging Sci 2011;1:15 doi:10.4103/2156-7514.76693 pmid:21977388
    CrossRefPubMed
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Cite this article
C. Zamora, S.-C. Hung, C. Tomingas, C. Atkinson, M. Castillo
Engorgement of Deep Medullary Veins in Neurosarcoidosis: A Common-Yet-Underrecognized Cerebrovascular Finding on SWI
American Journal of Neuroradiology Nov 2018, 39 (11) 2045-2050; DOI: 10.3174/ajnr.A5783

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Engorgement of Deep Medullary Veins in Neurosarcoidosis: A Common-Yet-Underrecognized Cerebrovascular Finding on SWI
C. Zamora, S.-C. Hung, C. Tomingas, C. Atkinson, M. Castillo
American Journal of Neuroradiology Nov 2018, 39 (11) 2045-2050; DOI: 10.3174/ajnr.A5783
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