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American Journal of Neuroradiology

Index by author

February 01, 2018; Volume 39,Issue 2

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Dwyer, M.G.
1. EDITOR'S CHOICEAdult Brain
  
  Open Access
  Feasibility of Brain Atrophy Measurement in Clinical Routine without Prior Standardization of the MRI Protocol: Results from MS-MRIUS, a Longitudinal Observational, Multicenter Real-World Outcome Study in Patients with Relapsing-Remitting MS
  R. Zivadinov, N. Bergsland, J.R. Korn, M.G. Dwyer, N. Khan, J. Medin, J.C. Price, B. Weinstock-Guttman and D. Silva on behalf of the MS-MRIUS Study Group
  
  American Journal of Neuroradiology February 2018, 39 (2) 289-295; DOI: https://doi.org/10.3174/ajnr.A5442
  
  Brain atrophy outcomes of 590 patients were analyzed by the percentage brain volume change measured by structural image evaluation with normalization of atrophy on 2D-T1WI and 3D-T1WI and the percentage lateral ventricle volume change, measured by VIENA on 2D-T1WI and 3D-T1WI and NeuroSTREAM on T2-FLAIR examinations. The median annualized percentage brain volume change was -0.31% on 2D-T1WI and -0.38% on 3D-T1WI. The median annualized percentage lateral ventricle volume change was 0.95% on 2D-T1WI, 1.47% on 3D-T1WI, and 0.90% on T2-FLAIR. The authors conclude that brain atrophy was more readily assessed by estimating the percentage lateral ventricle volume change on T2-FLAIR compared with the percentage brain volume change or percentage lateral ventricle volume change using 2D- or 3D-T1WI.

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