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Twenty-three patients with relapsing-remitting MS underwent both conventional 3D-FLAIR and compressed sensing 3D-FLAIR on a 3T scanner (reduction in scan time 1 minute 25 seconds, 27%; compressed sensing factor of 1.3). Two blinded readers independently evaluated both conventional and compressed sensing FLAIR for image quality and the number of MS lesions visible in the periventricular, intra-juxtacortical, infratentorial, and optic nerve regions. Image quality and the number of MS lesions detected by the readers were similar between the 2 FLAIR acquisitions. Almost perfect agreement was found between the two FLAIR acquisitions for total MS lesion count. The authors conclude that at 3T, and with a compressed sensing factor of 1.3, 3D-FLAIR is 27% faster and preserves diagnostic performance for the detection of MS plaques.

This is a retrospective analysis of 59 patients who received only gadobutrol and 60 patients who received only linear gadolinium-based contrast agents. Linear gadolinium-based contrast agents included gadoversetamide, gadobenatedimeglumine, and gadodiamide. T1 signal intensity in the globus pallidus, dentate nucleus, and pons was measured on the precontrast portions of patients' first and seventh brain MRIs. The dentate nucleus/pons signal ratio increased in the linear gadolinium-based contrast agent group while no significant increase was seen in the gadobutrol group. The authors conclude that successive doses of gadobutrol do not result in T1 shortening compared with changes seen in linear gadolinium-based contrast agents.