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This is a retrospective analysis of 59 patients who received only gadobutrol and 60 patients who received only linear gadolinium-based contrast agents. Linear gadolinium-based contrast agents included gadoversetamide, gadobenatedimeglumine, and gadodiamide. T1 signal intensity in the globus pallidus, dentate nucleus, and pons was measured on the precontrast portions of patients' first and seventh brain MRIs. The dentate nucleus/pons signal ratio increased in the linear gadolinium-based contrast agent group while no significant increase was seen in the gadobutrol group. The authors conclude that successive doses of gadobutrol do not result in T1 shortening compared with changes seen in linear gadolinium-based contrast agents.