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Research ArticleAdult Brain

Cytotoxic Lesions of the Corpus Callosum Caused by Thermogenic Dietary Supplements

J.A. Galnares-Olalde, A.J. Vázquez-Mézquita, G. Gómez-Garza, D. Reyes-Vázquez, V. Higuera-Ortiz, M.A. Alegría-Loyola and A. Mendez-Dominguez
American Journal of Neuroradiology August 2019, 40 (8) 1304-1308; DOI: https://doi.org/10.3174/ajnr.A6116
J.A. Galnares-Olalde
aFrom the Internal Medicine Service (J.A.G.-O.)
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A.J. Vázquez-Mézquita
bRadiology Service (A.J.V.-M., G.G.-G., D.R.-V.)
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G. Gómez-Garza
bRadiology Service (A.J.V.-M., G.G.-G., D.R.-V.)
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D. Reyes-Vázquez
bRadiology Service (A.J.V.-M., G.G.-G., D.R.-V.)
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V. Higuera-Ortiz
cDepartment of Rheumatology (V.H.-O.)
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M.A. Alegría-Loyola
dNeurology Service (M.A.A.-L., A.M.-D.), The American British Cowdray Medical Center, Mexico City, Mexico.
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A. Mendez-Dominguez
dNeurology Service (M.A.A.-L., A.M.-D.), The American British Cowdray Medical Center, Mexico City, Mexico.
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Abstract

SUMMARY: Consumption of over-the-counter dietary supplements to reduce body weight is common among the population. Thermogenics are herbal combinations that claim to produce a fat-burning process through an increase in the cellular metabolic rate and greater cellular energy consumption, having a high risk for patients developing toxic leukoencephalopathy. We present a series of 6 patients with acute neurologic symptoms and MR imaging showing restricted diffusion and decreased apparent diffusion coefficient values (mean value, 400 mm2/s × 10−6) in the entire corpus callosum compatible with a cytotoxic lesion of the corpus callosum. Although patients responded favorably to the product discontinuation with rapid recovery of neurologic symptoms, there was a more prolonged resolution on imaging alterations. Because of the widespread availability and unregulated nature of thermogenic dietary supplements, physicians must be aware of the clinical and radiologic characteristics of these potential complications of their use.

ABBREVIATION:

CLOCC
cytotoxic lesion of the corpus callosum
  • © 2019 by American Journal of Neuroradiology
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American Journal of Neuroradiology: 40 (8)
American Journal of Neuroradiology
Vol. 40, Issue 8
1 Aug 2019
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J.A. Galnares-Olalde, A.J. Vázquez-Mézquita, G. Gómez-Garza, D. Reyes-Vázquez, V. Higuera-Ortiz, M.A. Alegría-Loyola, A. Mendez-Dominguez
Cytotoxic Lesions of the Corpus Callosum Caused by Thermogenic Dietary Supplements
American Journal of Neuroradiology Aug 2019, 40 (8) 1304-1308; DOI: 10.3174/ajnr.A6116

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Cytotoxic Lesions of the Corpus Callosum Caused by Thermogenic Dietary Supplements
J.A. Galnares-Olalde, A.J. Vázquez-Mézquita, G. Gómez-Garza, D. Reyes-Vázquez, V. Higuera-Ortiz, M.A. Alegría-Loyola, A. Mendez-Dominguez
American Journal of Neuroradiology Aug 2019, 40 (8) 1304-1308; DOI: 10.3174/ajnr.A6116
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