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- Antiamyloid Therapy and Cerebral Blood Flow Changes on MRI: A Potential Longitudinal Biomarker of Treatment Response?
AD is characterized by the accumulation of extracellular amyloid-β in the brain parenchyma and along the walls of cerebral blood vessels, leading to decreased CBF. CBF changes on ASL-MR could reflect clearance of amyloid-β on lecanemab therapy, raising the possibility that ASL-MR could serve as a tool for monitoring the neurovascular treatment response.
- Deep Invasion Volume of the Primary Nasopharyngeal Carcinoma Predicts Treatment Outcome
The results of this study on quantification of deep invasion of NPC showed that the tumors with a relatively large deep component compared with the superficial component had a poorer outcome. Specifically, volume of deep invasion in primary NPC (ratio of deep to the total primary tumor volume) was found to correlate with the presence of nodal metastases and the best predictor of outcome, especially distant metastases-free survival.