Research ArticleORIGINAL RESEARCH
Deep-Learning Reconstruction for 7T MP2RAGE and SPACE MRI: Improving Image Quality at High Acceleration Factors
Zeyu Liu, Vishal Patel, Xiangzhi Zhou, Shengzhen Tao, Thomas Yu, Jun Ma, Dominik Nickel, Patrick Liebig, Erin M. Westerhold, Hamed Mojahed, Vivek Gupta and Erik H. Middlebrooks
American Journal of Neuroradiology May 2025, ajnr.A8841; DOI: https://doi.org/10.3174/ajnr.A8841
Zeyu Liu
From the Department of Radiology, Mayo Clinic, Jacksonville, FL, USA (Z.L., X.Z., S.T., E.M.W., V.G., E.H.M.); Department of Radiology, Peking Union Medical College Hospital, Beijing, China (Z.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.Y.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.Y.); LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.Y.); Siemens Medical Solutions USA, Inc., Jacksonville, FL, USA (J.M.); MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany (P.L.); Siemens Medical Solutions USA, Inc., Scottsdale, AZ, USA (H.M.); Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA (H.M.)
Vishal Patel
From the Department of Radiology, Mayo Clinic, Jacksonville, FL, USA (Z.L., X.Z., S.T., E.M.W., V.G., E.H.M.); Department of Radiology, Peking Union Medical College Hospital, Beijing, China (Z.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.Y.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.Y.); LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.Y.); Siemens Medical Solutions USA, Inc., Jacksonville, FL, USA (J.M.); MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany (P.L.); Siemens Medical Solutions USA, Inc., Scottsdale, AZ, USA (H.M.); Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA (H.M.)
Xiangzhi Zhou
From the Department of Radiology, Mayo Clinic, Jacksonville, FL, USA (Z.L., X.Z., S.T., E.M.W., V.G., E.H.M.); Department of Radiology, Peking Union Medical College Hospital, Beijing, China (Z.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.Y.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.Y.); LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.Y.); Siemens Medical Solutions USA, Inc., Jacksonville, FL, USA (J.M.); MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany (P.L.); Siemens Medical Solutions USA, Inc., Scottsdale, AZ, USA (H.M.); Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA (H.M.)
Shengzhen Tao
From the Department of Radiology, Mayo Clinic, Jacksonville, FL, USA (Z.L., X.Z., S.T., E.M.W., V.G., E.H.M.); Department of Radiology, Peking Union Medical College Hospital, Beijing, China (Z.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.Y.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.Y.); LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.Y.); Siemens Medical Solutions USA, Inc., Jacksonville, FL, USA (J.M.); MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany (P.L.); Siemens Medical Solutions USA, Inc., Scottsdale, AZ, USA (H.M.); Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA (H.M.)
Thomas Yu
From the Department of Radiology, Mayo Clinic, Jacksonville, FL, USA (Z.L., X.Z., S.T., E.M.W., V.G., E.H.M.); Department of Radiology, Peking Union Medical College Hospital, Beijing, China (Z.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.Y.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.Y.); LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.Y.); Siemens Medical Solutions USA, Inc., Jacksonville, FL, USA (J.M.); MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany (P.L.); Siemens Medical Solutions USA, Inc., Scottsdale, AZ, USA (H.M.); Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA (H.M.)
Jun Ma
From the Department of Radiology, Mayo Clinic, Jacksonville, FL, USA (Z.L., X.Z., S.T., E.M.W., V.G., E.H.M.); Department of Radiology, Peking Union Medical College Hospital, Beijing, China (Z.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.Y.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.Y.); LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.Y.); Siemens Medical Solutions USA, Inc., Jacksonville, FL, USA (J.M.); MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany (P.L.); Siemens Medical Solutions USA, Inc., Scottsdale, AZ, USA (H.M.); Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA (H.M.)
Dominik Nickel
From the Department of Radiology, Mayo Clinic, Jacksonville, FL, USA (Z.L., X.Z., S.T., E.M.W., V.G., E.H.M.); Department of Radiology, Peking Union Medical College Hospital, Beijing, China (Z.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.Y.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.Y.); LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.Y.); Siemens Medical Solutions USA, Inc., Jacksonville, FL, USA (J.M.); MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany (P.L.); Siemens Medical Solutions USA, Inc., Scottsdale, AZ, USA (H.M.); Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA (H.M.)
Patrick Liebig
From the Department of Radiology, Mayo Clinic, Jacksonville, FL, USA (Z.L., X.Z., S.T., E.M.W., V.G., E.H.M.); Department of Radiology, Peking Union Medical College Hospital, Beijing, China (Z.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.Y.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.Y.); LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.Y.); Siemens Medical Solutions USA, Inc., Jacksonville, FL, USA (J.M.); MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany (P.L.); Siemens Medical Solutions USA, Inc., Scottsdale, AZ, USA (H.M.); Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA (H.M.)
Erin M. Westerhold
From the Department of Radiology, Mayo Clinic, Jacksonville, FL, USA (Z.L., X.Z., S.T., E.M.W., V.G., E.H.M.); Department of Radiology, Peking Union Medical College Hospital, Beijing, China (Z.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.Y.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.Y.); LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.Y.); Siemens Medical Solutions USA, Inc., Jacksonville, FL, USA (J.M.); MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany (P.L.); Siemens Medical Solutions USA, Inc., Scottsdale, AZ, USA (H.M.); Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA (H.M.)
Hamed Mojahed
From the Department of Radiology, Mayo Clinic, Jacksonville, FL, USA (Z.L., X.Z., S.T., E.M.W., V.G., E.H.M.); Department of Radiology, Peking Union Medical College Hospital, Beijing, China (Z.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.Y.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.Y.); LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.Y.); Siemens Medical Solutions USA, Inc., Jacksonville, FL, USA (J.M.); MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany (P.L.); Siemens Medical Solutions USA, Inc., Scottsdale, AZ, USA (H.M.); Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA (H.M.)
Vivek Gupta
From the Department of Radiology, Mayo Clinic, Jacksonville, FL, USA (Z.L., X.Z., S.T., E.M.W., V.G., E.H.M.); Department of Radiology, Peking Union Medical College Hospital, Beijing, China (Z.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.Y.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.Y.); LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.Y.); Siemens Medical Solutions USA, Inc., Jacksonville, FL, USA (J.M.); MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany (P.L.); Siemens Medical Solutions USA, Inc., Scottsdale, AZ, USA (H.M.); Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA (H.M.)
Erik H. Middlebrooks
From the Department of Radiology, Mayo Clinic, Jacksonville, FL, USA (Z.L., X.Z., S.T., E.M.W., V.G., E.H.M.); Department of Radiology, Peking Union Medical College Hospital, Beijing, China (Z.L.); Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland (T.Y.); Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland (T.Y.); LTS5, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland (T.Y.); Siemens Medical Solutions USA, Inc., Jacksonville, FL, USA (J.M.); MR Application Predevelopment, Siemens Healthineers AG, Forchheim, Germany (P.L.); Siemens Medical Solutions USA, Inc., Scottsdale, AZ, USA (H.M.); Department of Radiology, Mayo Clinic, Scottsdale, AZ, USA (H.M.)

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Accepted Manuscript
Zeyu Liu, Vishal Patel, Xiangzhi Zhou, Shengzhen Tao, Thomas Yu, Jun Ma, Dominik Nickel, Patrick Liebig, Erin M. Westerhold, Hamed Mojahed, Vivek Gupta, Erik H. Middlebrooks
Deep-Learning Reconstruction for 7T MP2RAGE and SPACE MRI: Improving Image Quality at High Acceleration Factors
American Journal of Neuroradiology May 2025, ajnr.A8841; DOI: 10.3174/ajnr.A8841
Accepted Manuscript
Deep-Learning Reconstruction for 7T MP2RAGE and SPACE MRI: Improving Image Quality at High Acceleration Factors
Zeyu Liu, Vishal Patel, Xiangzhi Zhou, Shengzhen Tao, Thomas Yu, Jun Ma, Dominik Nickel, Patrick Liebig, Erin M. Westerhold, Hamed Mojahed, Vivek Gupta, Erik H. Middlebrooks
American Journal of Neuroradiology May 2025, ajnr.A8841; DOI: 10.3174/ajnr.A8841
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