RT Journal Article
SR Electronic
T1 The Effect of Hydroxyurea on Vasculopathy in a Child with Sickle Cell Disease
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1692
OP 1696
VO 23
IS 10
A1 Helton, Kathleen J.
A1 Wang, Winfred C.
A1 Wynn, Lynn W.
A1 Khan, Raja B.
A1 Steen, R. Grant
YR 2002
UL http://www.ajnr.org/content/23/10/1692.abstract
AB Summary: We report serial CNS findings in a girl with sickle cell disease and stroke. Religious considerations precluded transfusion and bone marrow transplantation; therefore, she received single-agent hydroxyurea therapy for almost 6 years. MR angiography showed that vascular patency improved, although diffuse cerebral atrophy slowly worsened. Hydroxyurea can be effective in treating vasculopathy, but it might not prevent the progression of parenchymal damage in advanced disease.