PT  - JOURNAL ARTICLE
AU  - Sayin, Ece Su
AU  - Duffin, James
AU  - Stumpo, Vittorio
AU  - Bellomo, Jacopo
AU  - Piccirelli, Marco
AU  - Poublanc, Julien
AU  - Wijeya, Vepeson
AU  - Para, Andrea
AU  - Pangalu, Athina
AU  - Bink, Andrea
AU  - Nemeth, Bence
AU  - Kulcsar, Zsolt
AU  - Mikulis, David J.
AU  - Fisher, Joseph A.
AU  - Sobczyk, Olivia
AU  - Fierstra, Jorn
TI  - Assessing Perfusion in Steno-Occlusive Cerebrovascular Disease Using Transient Hypoxia-Induced Deoxyhemoglobin as a Dynamic Susceptibility Contrast Agent
AID  - 10.3174/ajnr.A8068
DP  - 2024 Jan 01
TA  - American Journal of Neuroradiology
PG  - 37--43
VI  - 45
IP  - 1
4099  - http://www.ajnr.org/content/45/1/37.short
4100  - http://www.ajnr.org/content/45/1/37.full
SO  - Am. J. Neuroradiol.2024 Jan 01; 45
AB  - BACKGROUND AND PURPOSE: Resting brain tissue perfusion in cerebral steno-occlusive vascular disease can be assessed by MR imaging using gadolinium-based susceptibility contrast agents. Recently, transient hypoxia-induced deoxyhemoglobin has been investigated as a noninvasive MR imaging contrast agent. Here we present a comparison of resting perfusion metrics using transient hypoxia-induced deoxyhemoglobin and gadolinium-based contrast agents in patients with known cerebrovascular steno-occlusive disease.MATERIALS AND METHODS: Twelve patients with steno-occlusive disease underwent DSC MR imaging using a standard bolus of gadolinium-based contrast agent compared with transient hypoxia-induced deoxyhemoglobin generated in the lungs using an automated gas blender. A conventional multi-slice 2D gradient echo sequence was used to acquire the perfusion data and analyzed using a standard tracer kinetic model. MTT, relative CBF, and relative CBV maps were generated and compared between contrast agents.RESULTS: The spatial distributions of the perfusion metrics generated with both contrast agents were consistent. Perfusion metrics in GM and WM were not statistically different except for WM MTT.CONCLUSIONS: Cerebral perfusion metrics generated with noninvasive transient hypoxia-induced changes in deoxyhemoglobin are very similar to those generated using a gadolinium-based contrast agent in patients with cerebrovascular steno-occlusive disease.BOLDblood oxygen level–dependentCNRcontrast-to-noise ratioΔSBOLD signal changedOHbdeoxyhemoglobinGBCAgadolinium-based contrast agentsPETO2end-tidal partial pressure of oxygenPO2partial pressure of oxygenrCBFrelative CBFrCBVrelative CBVTHx-dOHbtransient hypoxia-induced deoxyhemoglobin