PT  - JOURNAL ARTICLE
AU  - Berman, Jeffrey I.
AU  - Bloy, Luke
AU  - Ward, Shana
AU  - Roberts, Timothy P.L.
TI  - Delta Wave MRI: fMRI of Electrophysiologic Activity
AID  - 10.3174/ajnr.A8618
DP  - 2025 Jun 01
TA  - American Journal of Neuroradiology
PG  - 1203--1207
VI  - 46
IP  - 6
4099  - http://www.ajnr.org/content/46/6/1203.short
4100  - http://www.ajnr.org/content/46/6/1203.full
SO  - Am. J. Neuroradiol.2025 Jun 01; 46
AB  - SUMMARY: We propose a novel application of MR encephalography (MREG) to detect the frequency spectrum of endogenous slow oscillatory brain activity (delta, <4 Hz). MREG offers faster image acquisition than conventional fMRI and superior spatial localization than electroencephalography/magnetoencephalography. MREG was acquired at a 0.1-second temporal resolution in a healthy adult during interleaved wakefulness and sleep to demonstrate its capability for detecting delta-band power changes associated with sleep, previously demonstrated by electroencephalography. For each voxel, the brain activity of MREG signal was used to compute a spectrogram and a whole-brain image of delta-band spectral power. The delta-band power was observed to increase during sleep compared with the awake states using measures from MREG voxelwise spectrograms and sequential whole-brain spatial maps of slow-wave power. This work introduces an MR technique for measuring brain slow-wave activity that is sensitive to changes in the magnitude and frequency of brain activity in sleep. BOLDblood oxygen level–dependentEEGelectroencephalographyMEGmagnetoencephalographyMREGMR encephalography