PT  - JOURNAL ARTICLE
AU  - van der Bom, I.M.J.
AU  - Mehra, M.
AU  - Walvick, R.P.
AU  - Chueh, J.-Y.
AU  - Gounis, M.J.
TI  - Quantitative Evaluation of C-Arm CT Cerebral Blood Volume in a Canine Model of Ischemic Stroke
AID  - 10.3174/ajnr.A2944
DP  - 2012 Feb 01
TA  - American Journal of Neuroradiology
PG  - 353--358
VI  - 33
IP  - 2
4099  - http://www.ajnr.org/content/33/2/353.short
4100  - http://www.ajnr.org/content/33/2/353.full
SO  - Am. J. Neuroradiol.2012 Feb 01; 33
AB  - BACKGROUND AND PURPOSE: Previous studies have shown the feasibility of assessing qualitative CBV measurements in the angiography suite by using FPD-CBCT systems. We have investigated the correlation of FPD-CBCT CBV lesion volumes to the infarct volume. MATERIALS AND METHODS: Unilateral strokes were created in 7 adult dogs. MR imaging and FPD-CBCT data were obtained after MCA occlusion. FPD-CBCT CBV and ADC maps were generated for all subjects. The animals were sacrificed immediately following the last imaging study to measure infarct volume on histology. The reliability of FPD-CBCT-based lesion volume measurements was compared with those measured histologically by using regression and Bland-Altman analysis. RESULTS: The best correlation (R2 = 0.72) between lesion volumes assessed with FPD-CBCT and histology was established with a threshold of mean healthy CBV − 2.5 × SD. These results were inferior to the correlation of lesion volumes measured with ADC and histology (R2 = 0.99). Bland-Altman analysis showed that the agreement of ADC-derived lesion volumes with histology was superior to the agreement of FPD-CBCT-derived lesion volumes with histology. CONCLUSIONS: We correlated FPD-CBCT measurements of CBV and MR ADC lesion volumes with histologically assessed infarct volume. As expected, ADC is a very accurate and precise method for determining the extent of infarction. FPD-CBCT CBV lesion volumes are correlated to the size of the infarct. Improvement of FPD-CBCT image quality provides an opportunity to establish quantitative CBV measurement in the angiography suite. CTPCT perfusionFPD-CBCTflat panel detector conebeam CTHUHounsfield unitsNSAnumber of signal-intensity averagesR2coefficient of determinationRMSEroot-mean-square errorσSD, standard deviationtlesionlesion thresholdTOFtime-of-flightTTC2,3,5-triphenyltetrazolium chlorideVlesionlesion volume