RT Journal Article
SR Electronic
T1 MR findings in methotrexate-induced CNS abnormalities.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 959
OP 964
VO 10
IS 5
A1 Ebner, F
A1 Ranner, G
A1 Slavc, I
A1 Urban, C
A1 Kleinert, R
A1 Radner, H
A1 Einspieler, R
A1 Justich, E
YR 1989
UL http://www.ajnr.org/content/10/5/959.abstract
AB MR of the brain was performed in eight patients (mean age, 14.9 years) with osteogenic sarcoma during or after IV treatment with high-dose methotrexate. MR detected brain abnormalities in four patients, three of whom had concomitant neurologic dysfunction. Pathologic findings demonstrated on MR were (1) chronic brain edema, demonstrable over a period of 3-14 months (proved by autopsy in one patient); (2) multifocal white matter necrosis; and (3) deep brain atrophy. MR appears to be valuable in the detection of abnormalities induced by treatment with high-dose methotrexate.