PT  - JOURNAL ARTICLE
AU  - Mukherji, S K
AU  - Schiro, S
AU  - Castillo, M
AU  - Kwock, L
AU  - Soper, R
AU  - Blackstock, W
AU  - Shockley, W
AU  - Weissler, M
TI  - Proton MR spectroscopy of squamous cell carcinoma of the upper aerodigestive tract: in vitro characteristics.
DP  - 1996 Sep 01
TA  - American Journal of Neuroradiology
PG  - 1485--1490
VI  - 17
IP  - 8
4099  - http://www.ajnr.org/content/17/8/1485.short
4100  - http://www.ajnr.org/content/17/8/1485.full
SO  - Am. J. Neuroradiol.1996 Sep 01; 17
AB  - PURPOSE To determine the ability of in vitro high-field-strength proton MR spectroscopy to differentiate squamous cell carcinoma of the upper aerodigestive tract from uninvolved muscle.METHODS Surgical specimens of squamous cell carcinoma arising from the upper aerodigestive tract (n = 18) and from muscle (n = 13) were examined in vitro using high-field (11 T) proton MR spectroscopy. The peak heights of choline and creatine were measured for tumor and muscle at echo times of 136 and 272. The choline/creatine (Cho/Cr) ratio was compared between tumor and normal tissue for each echo time. Student's t test was used to determine whether a significant difference existed between proton MR spectroscopic measurements of the Cho/Cr ratio for tumor and muscle.RESULTS The mean Cho/Cr ratio was consistently higher in tumor than in muscle at all echo times; however, statistically significant differences between tumor and muscle were identified only at longer echo times (136 and 272).CONCLUSION The Cho/Cr peak height ratio can be used to differentiate tumor from muscle in vitro (at 11 T).