RT Journal Article
SR Electronic
T1 Diffusion into human intervertebral disks studied with MR and gadoteridol.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 443
OP 445
VO 18
IS 3
A1 Akansel, G
A1 Haughton, V M
A1 Papke, R A
A1 Censky, S
YR 1997
UL http://www.ajnr.org/content/18/3/443.abstract
AB PURPOSE To determine the feasibility of measuring diffusion into human intervertebral disks by means of MR imaging with an intravenous nonionic gadolinium complex (gadoteridol).METHODS In 18 patients undergoing lumbar spine MR imaging, signal intensity was measured in the intervertebral disks after a dose of 0.1 mmol/kg and after a supplemental dose of 0.2 mmol/kg.RESULTS Signal intensity in the intervertebral disks increased with both gadoteridol doses. A greater increase was consistently achieved with the 0.3 mmol/kg (total) dose than with the 0.1 mmol/kg dose. The increase was greater near the endplates than in the midportion of the disk.CONCLUSION Diffusion into human intervertebral disks can be detected with MR imaging after intravenous administration of gadoteridol. MR imaging with a paramagnetic contrast medium can be used to study diffusion into disk cartilage in vivo and noninvasively.