PT  - JOURNAL ARTICLE
AU  - Engelbrecht, V
AU  - Rassek, M
AU  - Huismann, J
AU  - Wendel, U
TI  - MR and proton MR spectroscopy of the brain in hyperhomocysteinemia caused by methylenetetrahydrofolate reductase deficiency.
DP  - 1997 Mar 01
TA  - American Journal of Neuroradiology
PG  - 536--539
VI  - 18
IP  - 3
4099  - http://www.ajnr.org/content/18/3/536.short
4100  - http://www.ajnr.org/content/18/3/536.full
SO  - Am. J. Neuroradiol.1997 Mar 01; 18
AB  - MR imaging showed severe atrophy and large areas without myelination in the brain of a girl with methylenetetrahydrofolate reductase deficiency. Proton MR spectroscopy revealed mild signal reduction of N-acetylaspartate. After treatment with betaine, a second MR imaging study revealed a decrease in the size of the hypomyelinated zones that was paralleled by improved clinical status and laboratory findings.