PT  - JOURNAL ARTICLE
AU  - Szikora, I
AU  - Wakhloo, A K
AU  - Guterman, L R
AU  - Chavis, T D
AU  - Dawson, R C
AU  - Hergenrother, R W
AU  - Twyford, R H
AU  - Hopkins, L N
TI  - Initial experience with collagen-filled Guglielmi detachable coils for endovascular treatment of experimental aneurysms.
DP  - 1997 Apr 01
TA  - American Journal of Neuroradiology
PG  - 667--672
VI  - 18
IP  - 4
4099  - http://www.ajnr.org/content/18/4/667.short
4100  - http://www.ajnr.org/content/18/4/667.full
SO  - Am. J. Neuroradiol.1997 Apr 01; 18
AB  - PURPOSE To evaluate the effectiveness of Guglielmi detachable coils (GDCs) filled with collagen threads in the permanent treatment of experimental aneurysms.METHODS Seventeen side-wall aneurysms were surgically constructed in the canine common carotid artery; six were treated with conventional GDCs and 11 with collagen-filled GDCs. One aneurysms was removed at 1 week, the others were studied by digital subtraction angiography for a period of 8 to 12 weeks. Longitudinal sections of all aneurysms were examined by light microscopy.RESULTS Angiograms obtained throughout the follow-up period showed no significant difference between aneurysms treated with conventional GDCs and those treated with collagen-filled GDCs. Light microscopy revealed a dense meshwork of newly formed collagen and fibroblasts near the collagen-filled GDCs, whereas a loose cellular meshwork surrounded the conventional GDCs at 8 and 12 weeks after treatment.CONCLUSION Collagen threads within GDCs do not noticeably improve angiographic treatment of experimental aneurysms; however, these threads did induce local proliferation of fibroblasts and production of collagen within the aneurysmal cavities.