RT Journal Article
SR Electronic
T1 Initial experience with collagen-filled Guglielmi detachable coils for endovascular treatment of experimental aneurysms.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 667
OP 672
VO 18
IS 4
A1 Szikora, I
A1 Wakhloo, A K
A1 Guterman, L R
A1 Chavis, T D
A1 Dawson, R C
A1 Hergenrother, R W
A1 Twyford, R H
A1 Hopkins, L N
YR 1997
UL http://www.ajnr.org/content/18/4/667.abstract
AB PURPOSE To evaluate the effectiveness of Guglielmi detachable coils (GDCs) filled with collagen threads in the permanent treatment of experimental aneurysms.METHODS Seventeen side-wall aneurysms were surgically constructed in the canine common carotid artery; six were treated with conventional GDCs and 11 with collagen-filled GDCs. One aneurysms was removed at 1 week, the others were studied by digital subtraction angiography for a period of 8 to 12 weeks. Longitudinal sections of all aneurysms were examined by light microscopy.RESULTS Angiograms obtained throughout the follow-up period showed no significant difference between aneurysms treated with conventional GDCs and those treated with collagen-filled GDCs. Light microscopy revealed a dense meshwork of newly formed collagen and fibroblasts near the collagen-filled GDCs, whereas a loose cellular meshwork surrounded the conventional GDCs at 8 and 12 weeks after treatment.CONCLUSION Collagen threads within GDCs do not noticeably improve angiographic treatment of experimental aneurysms; however, these threads did induce local proliferation of fibroblasts and production of collagen within the aneurysmal cavities.