PT  - JOURNAL ARTICLE
AU  - Bowen, J
AU  - Richards, T
AU  - Maravilla, K
TI  - MR imaging and proton MR spectroscopy in A-to-G substitution at nucleotide position 3243 of leucine transfer RNA.
DP  - 1998 Feb 01
TA  - American Journal of Neuroradiology
PG  - 231--234
VI  - 19
IP  - 2
4099  - http://www.ajnr.org/content/19/2/231.short
4100  - http://www.ajnr.org/content/19/2/231.full
SO  - Am. J. Neuroradiol.1998 Feb 01; 19
AB  - MR imaging of the brain in a 38-year-old woman with maternally inherited diabetes and deafness (MIDD) showed extensive subcortical and basal ganglia high signal intensity on T2-weighted studies though she was neurologically asymptomatic. High-signal-intensity changes were also seen in the basal ganglia on T1-weighted studies. Proton MR spectroscopy showed increased lactate, an increased choline/creatine ratio, and a decreased N-acetylaspartate/creatine ratio. Our observations suggest that patients with MIDD may have subclinical neurologic dysfunction identifiable by proton MR spectroscopy.