RT Journal Article
SR Electronic
T1 MR imaging and proton MR spectroscopy in A-to-G substitution at nucleotide position 3243 of leucine transfer RNA.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 231
OP 234
VO 19
IS 2
A1 Bowen, J
A1 Richards, T
A1 Maravilla, K
YR 1998
UL http://www.ajnr.org/content/19/2/231.abstract
AB MR imaging of the brain in a 38-year-old woman with maternally inherited diabetes and deafness (MIDD) showed extensive subcortical and basal ganglia high signal intensity on T2-weighted studies though she was neurologically asymptomatic. High-signal-intensity changes were also seen in the basal ganglia on T1-weighted studies. Proton MR spectroscopy showed increased lactate, an increased choline/creatine ratio, and a decreased N-acetylaspartate/creatine ratio. Our observations suggest that patients with MIDD may have subclinical neurologic dysfunction identifiable by proton MR spectroscopy.