PT  - JOURNAL ARTICLE
AU  - Pavlakis, S G
AU  - Lu, D
AU  - Frank, Y
AU  - Wiznia, A
AU  - Eidelberg, D
AU  - Barnett, T
AU  - Hyman, R A
TI  - Brain lactate and N-acetylaspartate in pediatric AIDS encephalopathy.
DP  - 1998 Feb 01
TA  - American Journal of Neuroradiology
PG  - 383--385
VI  - 19
IP  - 2
4099  - http://www.ajnr.org/content/19/2/383.short
4100  - http://www.ajnr.org/content/19/2/383.full
SO  - Am. J. Neuroradiol.1998 Feb 01; 19
AB  - Two children with acquired immunodeficiency syndrome (AIDS) and progressive encephalopathy underwent MR spectroscopy before and after antiretroviral therapy. Initial MR spectroscopy of the basal ganglia region showed decreased N-acetylaspartate (NAA)/creatine (Cr) and a lactate peak. After therapy, there was improvement in NAA/Cr and an absence of the abnormal lactate peak. We suggest that decreased NAA/Cr in AIDS is reversible, that brain lactate might correlate with inflammation, and that MR spectroscopy can be useful in treatment trials.