RT Journal Article
SR Electronic
T1 Brain lactate and N-acetylaspartate in pediatric AIDS encephalopathy.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 383
OP 385
VO 19
IS 2
A1 Pavlakis, S G
A1 Lu, D
A1 Frank, Y
A1 Wiznia, A
A1 Eidelberg, D
A1 Barnett, T
A1 Hyman, R A
YR 1998
UL http://www.ajnr.org/content/19/2/383.abstract
AB Two children with acquired immunodeficiency syndrome (AIDS) and progressive encephalopathy underwent MR spectroscopy before and after antiretroviral therapy. Initial MR spectroscopy of the basal ganglia region showed decreased N-acetylaspartate (NAA)/creatine (Cr) and a lactate peak. After therapy, there was improvement in NAA/Cr and an absence of the abnormal lactate peak. We suggest that decreased NAA/Cr in AIDS is reversible, that brain lactate might correlate with inflammation, and that MR spectroscopy can be useful in treatment trials.