RT Journal Article
SR Electronic
T1 The Proteus syndrome: CNS manifestations.
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 987
OP 990
VO 19
IS 5
A1 Dietrich, R B
A1 Glidden, D E
A1 Roth, G M
A1 Martin, R A
A1 Demo, D S
YR 1998
UL http://www.ajnr.org/content/19/5/987.abstract
AB Proteus syndrome is a complex hamartomatous disorder characterized by multiple, diverse, somatic manifestations. We present a case in which severe, evolving CNS abnormalities were also exhibited. Imaging findings at presentation included hemimegalencephaly, subependymal calcified nodules, and periventricular cysts. Subsequently, dural sinus thrombosis developed. Eight previously reported patients may also have had hemimegalencephaly. When neuroimaging studies show hemimegalencephaly in a child with pigmented skin lesions, Proteus syndrome should be considered in the differential diagnosis.