PT  - JOURNAL ARTICLE
AU  - Sarikaya, B.
AU  - McKinney, A.M.
AU  - Spilseth, B.
AU  - Truwit, C.L.
TI  - Comparison of Spin-Echo T1- and T2-Weighted and Gradient-Echo T1-Weighted Images at 3T in Evaluating Very Preterm Neonates at Term-Equivalent Age
AID  - 10.3174/ajnr.A3323
DP  - 2013 May 01
TA  - American Journal of Neuroradiology
PG  - 1098--1103
VI  - 34
IP  - 5
4099  - http://www.ajnr.org/content/34/5/1098.short
4100  - http://www.ajnr.org/content/34/5/1098.full
SO  - Am. J. Neuroradiol.2013 May 01; 34
AB  - SUMMARY: Term-equivalent imaging can assess myelination status in very preterm infants (<30 weeks' gestational age at birth). However, myelination assessment has yet to be compared among GRE-T1WI, SE-T1WI, and SE-T2WI at 3T. We aimed to compare the rates of myelination among those 3 sequences in 11 very preterm neonates who underwent 3T MR imaging at term-equivalent age and subsequently had normal neurologic development. On each sequence, 2 neuroradiologists individually assessed 22 structures. SE-T2WI depicted a higher myelination rate (present in 58.2%–66.4% of all structures) than either GRE-T1WI (51.6%–63.9%) or SE-T1WI (20.5%–38.5%), while GRE-T1WI had the highest interobserver agreement (κ, 0.56; P < .0001). Myelination was present in 90%–100% of patients within the corpus callosum splenium, DSCP, ICP, lateral lemniscus, and spinal tract/nucleus of cranial nerve V on SE-T2WI, and in the DSCP, ICP, lateral lemniscus, medial lemniscus, pyramidal decussation, PLIC, and superior cerebellar peduncle on GRE-T1WI, occurring in similar structures as previously shown at 1.5T and 1T. However, it is not clear whether these findings represent true myelination versus precursors to myelination. DSCPdecussation of superior cerebellar pedunclesGREgradient-recalled echoICPinferior cerebellar pedunclePLICposterior limb of the internal capsuleSEspin-echo