RT Journal Article
SR Electronic
T1 Severe Tacrolimus Leukoencephalopathy after Liver Transplantation
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2085
OP 2088
VO 24
IS 10
A1 Schuuring, Janneke
A1 Wesseling, Pieter
A1 Verrips, Aad
YR 2003
UL http://www.ajnr.org/content/24/10/2085.abstract
AB Summary: Tacrolimus is an immunosuppressive agent that can show a wide variety of neurologic side effects, including leukoencephalopathy. Although the prognosis is good—after cessation or dose reduction, complete recovery usually occurs—the differentiation with treatable diseases such as progressive multifocal encephalopathy can be difficult, making a stereotactic biopsy of the white matter lesion sometimes necessary. We describe the case of a 12-year-old girl with a severe, reversible tacrolimus-related leukoencephalopathy and only mild histopathologic abnormalities.