PT  - JOURNAL ARTICLE
AU  - Ding, Yong Hong
AU  - Dai, Daying
AU  - Lewis, Debra A.
AU  - Danielson, Mark A.
AU  - Kadirvel, Ramanathan
AU  - Mandrekar, Jayawant N.
AU  - Cloft, Harry J.
AU  - Kallmes, David F.
TI  - Can Neck Size in Elastase-Induced Aneurysms Be Controlled? A Prospective Study
DP  - 2005 Oct 01
TA  - American Journal of Neuroradiology
PG  - 2364--2367
VI  - 26
IP  - 9
4099  - http://www.ajnr.org/content/26/9/2364.short
4100  - http://www.ajnr.org/content/26/9/2364.full
SO  - Am. J. Neuroradiol.2005 Oct 01; 26
AB  - BACKGROUND AND PURPOSE: An earlier retrospective study indicated that the neck size of elastase-induced aneurysms could be controlled by adjusting the position of the inflated balloon. We report the current prospective study to confirm our previous work.METHODS: Ninety elastase-induced aneurysms were created in rabbits. Group 1 (n = 62) included cases in which the occlusion balloon resided low, completely within the brachiocephalic/subclavian arteries. Group 2 (n = 28) included cases in which the balloon resided high, within both the common carotid artery and brachiocephalic/subclavian arteries. Follow-up digital subtraction angiography was performed. The aneurysm sizes were measured and compared between groups. The Student t test and the Fisher exact test were used for statistical analysis.RESULTS: The mean aneurysm neck diameter and width for group 1 was significantly larger than that of group 2 (3.4 ± 1.2 and 2.3 ± 0.9 mm, P < .001; 3.8 ± 1.0 and 3.3 ± 0.9 mm, P < .05, respectively). The proportion of wide-necked aneurysms in group 1 was significantly larger than that in group 2 (29% vs 4%; P < .005). Mean dome-to-neck ratios were 1.2 ± 0.4 and 1.7 ± 0.7 for groups 1 and 2 (P < .005). There was no significant difference in aneurysm height between groups 1 and 2 (8.0 ± 1.7 and 7.5 ± 2.2 mm; P > .05).CONCLUSION: The neck size of elastase-induced aneurysm models in rabbits can be controlled by adjusting the position of the inflated balloon.