RT Journal Article
SR Electronic
T1 Serial Whole-Brain <em>N</em>-Acetylaspartate Concentration in Healthy Young Adults
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1650
OP 1651
DO 10.3174/ajnr.A0712
VO 28
IS 9
A1 Rigotti, D.J.
A1 Inglese, M.
A1 Babb, J.S.
A1 Rovaris, M.
A1 Benedetti, B.
A1 Filippi, M.
A1 Grossman, R.I.
A1 Gonen, O.
YR 2007
UL http://www.ajnr.org/content/28/9/1650.abstract
AB SUMMARY: Although the concentration of N-acetylaspartate (NAA) is often used as a neuronal integrity marker, its normal temporal variations are not well documented. To assess them over the 1–2 year periods of typical clinical trials, the whole-brain NAA concentration was measured longitudinally, over 4 years, in a cohort of healthy young adults. No significant change (adjusted for both sex and age) was measured either interpersonally or intrapersonally over the entire duration of the study.