RT Journal Article
SR Electronic
T1 Noninvasive Molecular Neuroimaging Using Reporter Genes: Part I, Principles Revisited
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 229
OP 234
DO 10.3174/ajnr.A0864
VO 29
IS 2
A1 Massoud, T.F.
A1 Singh, A.
A1 Gambhir, S.S.
YR 2008
UL http://www.ajnr.org/content/29/2/229.abstract
AB SUMMARY:In this first article, we review the basic principles of using reporter genes for molecular imaging of the brain in living subjects. This approach is emerging as a valuable tool for monitoring gene expression in diverse applications in laboratory animals, including the study of gene-targeted and trafficking cells, gene therapies, transgenic animals, and more complex molecular interactions within the central nervous system. Further development of more sensitive and selective reporters, combined with improvements in detection technology, will consolidate the position of in vivo reporter gene imaging as a versatile method for greater understanding of intracellular biologic processes and underlying molecular neuropathology and will potentially establish a future role in the clinical management of patients with neurologic diseases.