PT  - JOURNAL ARTICLE
AU  - Gupta, R.K.
AU  - Nath, K.
AU  - Prasad, A.
AU  - Prasad, K.N.
AU  - Husain, M.
AU  - Rathore, R.K.S.
AU  - Husain, N.
AU  - Srivastava, C.
AU  - Khetan, P.
AU  - Trivedi, R.
AU  - Narayana, P.A.
TI  - In Vivo Demonstration of Neuroinflammatory Molecule Expression in Brain Abscess with Diffusion Tensor Imaging
AID  - 10.3174/ajnr.A0826
DP  - 2008 Feb 01
TA  - American Journal of Neuroradiology
PG  - 326--332
VI  - 29
IP  - 2
4099  - http://www.ajnr.org/content/29/2/326.short
4100  - http://www.ajnr.org/content/29/2/326.full
SO  - Am. J. Neuroradiol.2008 Feb 01; 29
AB  - BACKGROUND AND PURPOSE: Neuroinflammatory molecules, including tumor necrosis factor-α, interleukin1-β, lymphocyte function associated molecule-1, and intercellular cell adhesion molecule-1 contribute to the development of brain abscess. We hypothesized that the high fractional anisotropy (FA) in the brain abscess cavity reflects the upregulation of these neuroinflammatory molecules.Materials and METHODS: Diffusion tensor imaging (DTI) was performed in 24 patients with brain abscess and Staphylococcus aureus–treated as well as nontreated Jurket cell lines (at 4 time points: 1, 24, 48, and 72 hours). Neuroinflammatory molecules were quantified from the brain abscess cavity aspirate of the patients as well as from the heat-killed S aureus–treated and nontreated cell lines and correlated with DTI measures.RESULTS: The DTI-derived FA strongly correlated with the presence of neuroinflammatory molecules in the pus as well as in S aureus–treated cell lines; no such correlation was observed in nontreated cell lines.CONCLUSIONS: These data indicate that neuroinflammatory molecules confer high diffusion anisotropy inside the brain abscess cavity. We propose that increased FA reflects upregulated inflammatory response in brain abscess.