RT Journal Article
SR Electronic
T1 Insights into Adult Postlesional Language Cortical Plasticity Provided by Cerebral Blood Oxygen Level–Dependent Functional MR Imaging
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 990
OP 996
DO 10.3174/ajnr.A1896
VO 31
IS 6
A1 Pillai, J.J.
YR 2010
UL http://www.ajnr.org/content/31/6/990.abstract
AB SUMMARY: BOLD fMRI has provided new insights into postlesional brain language plasticity by providing a noninvasive in vivo approach to evaluate longitudinal changes in brain cortical activation during performance of language tasks. Specifically, BOLD fMRI has provided the opportunity to investigate not only changes in eloquent language cortex resulting from different types of brain pathology such as brain tumors, stroke, and epilepsy but also changes in eloquent language cortex occurring as a result of actual surgical resection of diseased but, nevertheless, partially functional tissue. In addition to reviewing the literature relating to stroke and epilepsy-related language plasticity as well as the more intriguing phenomenon of postsurgical plasticity in the setting of brain tumors, 2 unusual cases illustrating this latter manifestation of language plasticity are briefly described in this review article. BOLDblood oxygen level−dependentDECSdirect electrical cortical stimulation (intraoperative mapping)fMRIfunctional MR imagingGABAgamma-aminobutyric acid (neurotransmitter)LleftLIlaterality indexLIFGleft inferior frontal gyrusMPRAGEmagnetization-prepared rapid acquisition gradient echoNVnoun-verb (association)Pphonological (rhyming)PETpositron-emission tomographyRrightRIFGright inferior frontal gyrusS1first (preoperative) fMRI scanning sessionS2second (first postoperative) fMRI scanning sessionS3third (second postoperative) fMRI scanning sessionSPMStatistical Parametric MappingTLEtemporal lobe epilepsy