RT Journal Article
SR Electronic
T1 Multiple Inflow Pulsed Arterial Spin-Labeling Reveals Delays in the Arterial Arrival Time in Minor Stroke and Transient Ischemic Attack
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1892
OP 1894
DO 10.3174/ajnr.A2008
VO 31
IS 10
A1 MacIntosh, B.J.
A1 Lindsay, A.C.
A1 Kylintireas, I.
A1 Kuker, W.
A1 Günther, M.
A1 Robson, M.D.
A1 Kennedy, J.
A1 Choudhury, R.P.
A1 Jezzard, P.
YR 2010
UL http://www.ajnr.org/content/31/10/1892.abstract
AB Our purpose was to use multiple inflow pulsed ASL to investigate whether hemodynamic AAT information is sensitive to hemispheric asymmetry in acute ischemia. The cohorts included 15 patients with acute minor stroke or TIA and 15 age-matched controls. Patients were scanned by using a stroke MR imaging protocol at a median time of 74 hours. DWI lesion volumes were small and functional impairment was low; however, perfusion abnormalities were evident. Prolonged AAT values were more likely to reside in the affected hemisphere (significant when compared with controls, P < .048). An advantage of this ASL technique is the ability to use AAT information in addition to CBF to characterize ischemia. AATarterial arrival timeASLarterial spin-labelingAUHarea under the histogramCBFcerebral blood flowDSCdynamic susceptibility contrastDWIdiffusion-weighted imagingFMRIBFunctional MRI of the BrainGRASEgradient and spin-echoICAinternal carotid arteryMCAmiddle cerebral arteryNIHSSNational Institutes of Health Stroke ScalePASLpulsed arterial spin-labelingTIAtransient ischemic attack