PT  - JOURNAL ARTICLE
AU  - Ding, Y.
AU  - Dai, D.
AU  - Kadirvel, R.
AU  - Lewis, D.A.
AU  - Kallmes, D.F.
TI  - Creation of Large Elastase-Induced Aneurysms: Presurgical Arterial Remodeling Using Arteriovenous Fistulas
AID  - 10.3174/ajnr.A2205
DP  - 2010 Nov 01
TA  - American Journal of Neuroradiology
PG  - 1935--1937
VI  - 31
IP  - 10
4099  - http://www.ajnr.org/content/31/10/1935.short
4100  - http://www.ajnr.org/content/31/10/1935.full
SO  - Am. J. Neuroradiol.2010 Nov 01; 31
AB  - BACKGROUND AND PURPOSE: The size of elastase-induced aneurysms created in the usual way is relatively small. Our aim was to determine whether creation of a carotid-jugular AVF to induce remodeling of the RCCA results in larger elastase-induced aneurysms in rabbits. MATERIALS AND METHODS: RCCA right-jugular AVFs were created in 6 New Zealand white rabbits (group 1), followed by elastase-induced aneurysm creation 4 weeks later. Follow-up DSA was performed to assess AVF patency and aneurysm sizes. Six other elastase-induced aneurysms created in the usual way were used as controls (group 2). The diameters of the RCCA and LCCA in group 1 and aneurysm sizes in both groups were measured from DSA images and compared by using the Student t test. RESULTS: The patency of AVFs in group 1 was confirmed in all 6 (100%) cases. The mean RCCA diameter in group 1 was larger than that in the contralateral LCCA (3.6 ± 0.7 mm versus 2.0 ± 0.1 mm, range, 1.8–2.2 mm, P < .01). The mean aneurysm neck diameter, width, and height for group 1 was larger than those of group 2 (4.6 ± 0.9 mm versus 3.5 ± 0.7 mm, P < .05; 4.7 ± 1.1 mm versus 3.4 ± 0.5 mm, P < .05; 13.8 ± 3.2 mm versus 8.1 ± 1.3 mm, P < .05, respectively). Aneurysm volume for group 1 was significantly larger than that of group 2 (273 ± 172 mm3 versus 77 ± 32 mm3, P < .05). CONCLUSIONS: Carotid-jugular AVFs result in RCCA remodeling that yields relatively larger elastase-induced aneurysms. AVFarteriovenous fistulaDSAdigital subtraction angiographyIADSAintra-arterial DSAIVDSAintravenous DSALCCAleft common carotid arteryRCCAright common carotid arteryREJVright external jugular vein