PT  - JOURNAL ARTICLE
AU  - Brasch, Robert C.
AU  - Nitecki, Danute E.
AU  - Brant-Zawadzki, Michael
AU  - Enzmann, Dieter R.
AU  - Wesbey, George E.
AU  - Tozer, Thomas N.
AU  - Tuck, L. Dallas
AU  - Cann, Christopher E.
AU  - Fike, John R.
AU  - Sheldon, Phillip
TI  - Brain Nuclear Magnetic Resonance Imaging Enhanced by a Paramagnetic Nitroxide Contrast Agent: Preliminary Report
DP  - 1983 Sep 01
TA  - American Journal of Neuroradiology
PG  - 1035--1039
VI  - 4
IP  - 5
4099  - http://www.ajnr.org/content/4/5/1035.short
4100  - http://www.ajnr.org/content/4/5/1035.full
SO  - Am. J. Neuroradiol.1983 Sep 01; 4
AB  - Contrast-enhancing agents for demonstrating abnormalities of the blood-brain barrier may extend the diagnostic utility of proton nuclear magnetic resonance (NMR) imaging. “TES,” a nitroxide stable free radical derivative, was tested as a central nervous system contrast enhancer in dogs with experimentally induced unilateral cerebritis or radiation cerebral damage. After intravenous injection of TES, the normal brain showed no change in NMR appearance, but areas of disease demonstrated a dramatic increase (up to 45%) in spin-echo intensity and a decrease in T1, relaxation times. The areas of disease defined by TES enhancement were either not evident on the nonenhanced NMR images or were better defined after contrast administration. In-depth tests of toxicity, stability, and metabolism of this promising NMR contrast agent are now in progress.