RT Journal Article
SR Electronic
T1 Clinically Relevant Imaging Features for <em>MGMT</em> Promoter Methylation in Multiple Glioblastoma Studies: A Systematic Review and Meta-Analysis
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1439
OP 1445
DO 10.3174/ajnr.A5711
VO 39
IS 8
A1 Suh, C.H.
A1 Kim, H.S.
A1 Jung, S.C.
A1 Choi, C.G.
A1 Kim, S.J.
YR 2018
UL http://www.ajnr.org/content/39/8/1439.abstract
AB BACKGROUND: O6-methylguanine methyltransferase (MGMT) promoter methylation status has been reported as a prognostic biomarker in clinical trials.PURPOSE: Our aim was to systematically evaluate imaging features of MGMT promoter methylated glioblastoma and to determine the diagnostic performance of MR imaging for prediction of MGMT promoter methylation in patients with newly diagnosed glioblastoma.DATA SOURCES: A computerized search of Ovid MEDLINE and EMBASE up to February 27, 2018, was conducted.STUDY SELECTION: We selected studies evaluating imaging features of MGMT promoter methylated glioblastoma and the diagnostic performance of MR imaging for prediction of MGMT promoter methylation.DATA ANALYSIS: Pooled estimates of sensitivity and specificity were calculated using a hierarchic logistic regression model. Meta-regression and sensitivity analysis were performed.DATA SYNTHESIS: Twenty-two articles including 2199 patients were included. MGMT promoter methylated glioblastoma is likely to show less edema, high ADC, and low perfusion. Ten articles including 753 patients were included in the meta-analysis. The summary sensitivity was 79% (95% CI, 72%–85%), and the summary specificity was 78% (95% CI, 71%–84%). In the meta-regression, MGMT promoter methylation and mean age were associated with heterogeneity. Sensitivity analysis excluding 1 study resolved the heterogeneity.LIMITATIONS: Included studies used a variety of different MR imaging techniques to predict MGMT promoter methylation.CONCLUSIONS: MGMT promotor methylated glioblastoma is likely to show less aggressive imaging features than MGMT promotor unmethylated glioblastoma. Despite the variety of different MR imaging techniques used, MR imaging in patients with newly diagnosed glioblastoma was shown to have the potential to predict MGMT promoter methylation noninvasively.DCEdynamic contrast-enhanced imagingHSROChierarchic summary receiver operating characteristicIDHisocitrate dehydrogenaseMGMTO6-methylguanine methyltransferasePRISMAPreferred Reporting Items for Systematic Reviews and Meta-AnalysesQUADAS-2Quality Assessment of Diagnostic Accuracy Studies-2WHOWorld Health Organization