PT  - JOURNAL ARTICLE
AU  - Grinberg, A.
AU  - Katorza, E.
AU  - Hoffman, D.
AU  - Ber, R.
AU  - Mayer, A.
AU  - Lipitz, S.
TI  - Volumetric MRI Study of the Brain in Fetuses with Intrauterine Cytomegalovirus Infection and Its Correlation to Neurodevelopmental Outcome
AID  - 10.3174/ajnr.A5948
DP  - 2019 Feb 01
TA  - American Journal of Neuroradiology
PG  - 353--358
VI  - 40
IP  - 2
4099  - http://www.ajnr.org/content/40/2/353.short
4100  - http://www.ajnr.org/content/40/2/353.full
SO  - Am. J. Neuroradiol.2019 Feb 01; 40
AB  - BACKGROUND AND PURPOSE: In recent years, effort has been made to study 3D biometry as a method for fetal brain assessment. In this study, we aimed to compare brain volumes of fetuses with cytomegalovirus infection and noninfected controls. Also, we wanted to assess whether there is a correlation to their neurodevelopmental outcome as observed after several years.MATERIALS AND METHODS: A retrospective cohort study examined MR imaging brain scans of 42 fetuses (at 30–34 weeks' gestational age) that were diagnosed with intrauterine cytomegalovirus infection. Volumetric measurements of 6 structures were assessed using a semiautomated designated program and were compared with a control group of 50 fetuses. Data collected included prenatal history and MR imaging and sonographic and neurodevelopmental follow-up.RESULTS: We found that all brain volumes measured were smaller in the cytomegalovirus-infected group and that there was a correlation between smaller cerebellar volume and lower Vineland II Adaptive Behavior Scales questionnaire scores, especially in the fields of daily living and communication skills.CONCLUSIONS: In this study, we found that brain volumes are affected by intrauterine cytomegalovirus infection and that it has a developmental prognostic meaning. Such information, which should be supported by further research, may help clinicians further analyze imaging data to treat and make a better assessment of these fetuses.CMVcytomegalovirusCVcerebellum volumeICCintraclass correlation coefficientLEBVleft eyeball volumeLHVleft hemisphere volumeREBVright eyeball volumeRHVright hemisphere volumeSTVsupratentorial volumeVABS-IIVineland II Adaptive Behavior Scale