PT  - JOURNAL ARTICLE
AU  - Ivanidze, J.
AU  - Mackay, M.
AU  - Hoang, A.
AU  - Chi, J.M.
AU  - Cheng, K.
AU  - Aranow, C.
AU  - Volpe, B.
AU  - Diamond, B.
AU  - Sanelli, P.C.
TI  - Dynamic Contrast-Enhanced MRI Reveals Unique Blood-Brain Barrier Permeability Characteristics in the Hippocampus in the Normal Brain
AID  - 10.3174/ajnr.A5962
DP  - 2019 Mar 01
TA  - American Journal of Neuroradiology
PG  - 408--411
VI  - 40
IP  - 3
4099  - http://www.ajnr.org/content/40/3/408.short
4100  - http://www.ajnr.org/content/40/3/408.full
SO  - Am. J. Neuroradiol.2019 Mar 01; 40
AB  - SUMMARY: We report a prospective dynamic contrast-enhanced MR imaging analysis of region-specific blood-brain barrier permeability in 5 healthy subjects. By means of standardized postprocessing and ROI sampling methods, the hippocampi revealed significantly elevated area under the dynamic contrast-enhanced curve and significantly increased blood-brain barrier permeability metrics (volume transfer constant and volume in the extravascular extracellular space) from model-based quantitation. These findings suggest unique blood-brain barrier permeability characteristics in the hippocampus, which are concordant with previous animal studies, potentially laying the groundwork for future studies assessing patient populations in which hippocampal pathology plays a role.BBBPblood-brain barrier permeabilityDCEdynamic contrast-enhancedKtransvolume transfer constantSLEsystemic lupus erythematosusVEvolume in the extravascular extracellular space