RT Journal Article SR Electronic T1 Focal Leptomeningeal Disease with Perivascular Invasion in EGFR-Mutant Non-Small-Cell Lung Cancer JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 1430 OP 1433 DO 10.3174/ajnr.A6640 VO 41 IS 8 A1 Dasgupta, A. A1 Moraes, F.Y. A1 Rawal, S. A1 Diamandis, P. A1 Shultz, D.B. YR 2020 UL http://www.ajnr.org/content/41/8/1430.abstract AB SUMMARY: We report a previously undescribed pattern of brain metastases in patients with epidermal growth factor receptor–mutated non-small-cell lung cancer treated with tyrosine kinase inhibitors and radiation therapy. These highly distinct lesions appear to spread focally within the leptomeninges, with invasion along the perivascular spaces (FLIP). The survival of patients with FLIP was significantly better compared with patients with classic leptomeningeal disease (median survival, 21 versus 3 months; P = .003). It is unclear whether this pattern of growth is unique to epidermal growth factor receptor–mutated non-small-cell lung cancer.EGFRmepidermal growth factor receptor–mutatedcLMDclassic leptomeningeal diseaseFLIPfocal leptomeningeal involvement with invasion of the perivascular spaceNSCLCnon-small-cell lung cancerTKItyrosine kinase inhibitorsWBRTwhole-brain radiation