RT Journal Article
SR Electronic
T1 Cytotoxic Lesion of the Corpus Callosum in an Adolescent with Multisystem Inflammatory Syndrome and SARS-CoV-2 Infection
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 2017
OP 2019
DO 10.3174/ajnr.A6755
VO 41
IS 11
A1 Lin, J.
A1 Lawson, E.C.
A1 Verma, S.
A1 Peterson, R.B.
A1 Sidhu, R.
YR 2020
UL http://www.ajnr.org/content/41/11/2017.abstract
AB SUMMARY: Multisystem inflammatory syndrome in children is a recently described complication in the late phase of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) infection involving systemic hyperinflammation and multiorgan dysfunction. The extent of its clinical picture is actively evolving and has yet to be fully elucidated. While neurologic manifestations of SARS-CoV-2 are well-described in the adult population, reports of neurologic complications in pediatric patients with SARS-CoV-2 infection are limited. We present a pediatric patient with SARS-CoV-2 infection with development of multisystem inflammatory syndrome and acute encephalopathy causing delirium who was found to have a cytotoxic lesion of the corpus callosum on neuroimaging. Cytotoxic lesions of the corpus callosum are a well-known, typically reversible entity that can occur in a wide range of conditions, including infection, seizure, toxins, nutritional deficiencies, and Kawasaki disease. We hypothesized that the cytotoxic lesion of the corpus callosum, in the index case, was secondary to the systemic inflammation from SARS-CoV-2 infection, resulting in multisystem inflammatory syndrome in children.CLOCCcytotoxic lesion of the corpus callosumCOVID-19coronavirus disease 2019IVIGintravenous immunoglobulinMIS-Cmultisystem inflammatory syndrome in childrenPCRpolymerase chain reactionSARS-CoV-2Severe Acute Respiratory Syndrome coronavirus 2