RT Journal Article
SR Electronic
T1 Brain MR Spectroscopic Findings in 3 Consecutive Patients with COVID-19: Preliminary Observations
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 37
OP 41
DO 10.3174/ajnr.A6877
VO 42
IS 1
A1 Rapalino, O.
A1 Weerasekera, A.
A1 Moum, S.J.
A1 Eikermann-Haerter, K.
A1 Edlow, B.L.
A1 Fischer, D.
A1 Torrado-Carvajal, A.
A1 Loggia, M.L.
A1 Mukerji, S.S.
A1 Schaefer, P.W.
A1 Gonzalez, R.G.
A1 Lev, M.H.
A1 Ratai, E.-M.
YR 2021
UL http://www.ajnr.org/content/42/1/37.abstract
AB SUMMARY: Brain multivoxel MR spectroscopic imaging was performed in 3 consecutive patients with coronavirus disease 2019 (COVID-19). These included 1 patient with COVID-19-associated necrotizing leukoencephalopathy, another patient who had a recent pulseless electrical activity cardiac arrest with subtle white matter changes, and a patient without frank encephalopathy or a recent severe hypoxic episode. The MR spectroscopic imaging findings were compared with those of 2 patients with white matter pathology not related to Severe Acute Respiratory Syndrome coronavirus 2 infection and a healthy control subject. The NAA reduction, choline elevation, and glutamate/glutamine elevation found in the patient with COVID-19-associated necrotizing leukoencephalopathy and, to a lesser degree, the patient with COVID-19 postcardiac arrest, follow a similar pattern as seen with the patient with delayed posthypoxic leukoencephalopathy. Lactate elevation was most pronounced in the patient with COVID-19 necrotizing leukoencephalopathy.COVID-19coronavirus disease 2019DPLdelayed posthypoxic leukoencephalopathyLaclactatePEApulseless electrical activitySAEsepsis-associated encephalopathySARS-CoV-2Severe Acute Respiratory Syndrome coronavirus 2