PT  - JOURNAL ARTICLE
AU  - Gongala, Sree
AU  - Garcia, Jose A.
AU  - Korakavi, Nisha
AU  - Patil, Nirav
AU  - Akbari, Hamed
AU  - Sloan, Andrew
AU  - Barnholtz-Sloan, Jill S.
AU  - Sun, Jessie
AU  - Griffith, Brent
AU  - Poisson, Laila M.
AU  - Booth, Thomas C.
AU  - Jain, Rajan
AU  - Mohan, Suyash
AU  - Nasralla, MacLean P.
AU  - Bakas, Spyridon
AU  - Tippareddy, Charit
AU  - Puig, Josep
AU  - Palmer, Joshua D.
AU  - Shi, Wenyin
AU  - Colen, Rivka R.
AU  - Sotiras, Aristeidis
AU  - Ahn, Sung Soo
AU  - Park, Yae Won
AU  - Davatzikos, Christos
AU  - Badve, Chaitra
AU - on behalf of the ReSPOND Consortium
TI  - Sex-Specific Differences in Patients with <em>IDH1</em>–Wild-Type Grade 4 Glioma in the ReSPOND Consortium
AID  - 10.3174/ajnr.A8319
DP  - 2024 Sep 01
TA  - American Journal of Neuroradiology
PG  - 1299--1307
VI  - 45
IP  - 9
4099  - http://www.ajnr.org/content/45/9/1299.short
4100  - http://www.ajnr.org/content/45/9/1299.full
SO  - Am. J. Neuroradiol.2024 Sep 01; 45
AB  - BACKGROUND AND PURPOSE: Understanding sex-based differences in patients with glioblastoma is necessary for accurate personalized treatment planning to improve patient outcomes. Our purpose was to investigate sex-specific differences in molecular, clinical, and radiologic tumor parameters, as well as survival outcomes in patients with glioblastoma, isocitrate dehydrogenase-1 wild-type (IDH1-WT), grade 4.MATERIALS AND METHODS: Retrospective data of 1832 patients with glioblastoma, IDH1-WT with comprehensive information on tumor parameters was acquired from the Radiomics Signatures for Precision Oncology in Glioblastoma consortium. Data imputation was performed for missing values. Sex-based differences in tumor parameters, such as age, molecular parameters, preoperative Karnofsky performance score (KPS), tumor volumes, epicenter, and laterality were assessed through nonparametric tests. Spatial atlases were generated by using preoperative MRI maps to visualize tumor characteristics. Survival time analysis was performed through log-rank tests and Cox proportional hazard analyses.RESULTS: Glioblastoma was diagnosed at a median age of 64 years in women compared with 61.9 years in men (false discovery rate [FDR] = 0.003). Men had a higher KPS (above 80) as compared with women (60.4% women versus 69.7% men, FDR = 0.044). Women had lower tumor volumes in enhancing (16.7 cm3 versus 20.6 cm3 in men, FDR = 0.001), necrotic core (6.18 cm3 versus 7.76 cm3 in men, FDR = 0.001), and edema regions (46.9 cm3 versus 59.2 cm3 in men, FDR = 0.0001). The right temporal region was the most common tumor epicenter in the overall population. Right as well as left temporal lobes were more frequently involved in men. There were no sex-specific differences in survival outcomes and mortality ratios. Higher age, unmethylated O6-methylguanine-DNA-methyltransferase promoter and undergoing subtotal resection increased the mortality risk in both men and women.CONCLUSIONS: Our study demonstrates significant sex-based differences in clinical and radiologic tumor parameters of patients with glioblastoma. Sex is not an independent prognostic factor for survival outcomes and the tumor parameters influencing patient outcomes are identical for men and women.EORextent of resectionFDRfalse discovery rateGTRgross total resectionIDH1-WTisocitrate dehydrogenase-1 wild-typeKPSKarnofsky performance scoreMGMTpO6-methylguanine-DNA-methyltransferase promoterMICEMultiple Imputation by Chained EquationsSTRsubtotal resectionUSUnited StatesWHOWorld Health Organization