RT Journal Article
SR Electronic
T1 Sex-Specific Differences in Patients with <em>IDH1</em>–Wild-Type Grade 4 Glioma in the ReSPOND Consortium
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1299
OP 1307
DO 10.3174/ajnr.A8319
VO 45
IS 9
A1 Gongala, Sree
A1 Garcia, Jose A.
A1 Korakavi, Nisha
A1 Patil, Nirav
A1 Akbari, Hamed
A1 Sloan, Andrew
A1 Barnholtz-Sloan, Jill S.
A1 Sun, Jessie
A1 Griffith, Brent
A1 Poisson, Laila M.
A1 Booth, Thomas C.
A1 Jain, Rajan
A1 Mohan, Suyash
A1 Nasralla, MacLean P.
A1 Bakas, Spyridon
A1 Tippareddy, Charit
A1 Puig, Josep
A1 Palmer, Joshua D.
A1 Shi, Wenyin
A1 Colen, Rivka R.
A1 Sotiras, Aristeidis
A1 Ahn, Sung Soo
A1 Park, Yae Won
A1 Davatzikos, Christos
A1 Badve, Chaitra
A1 on behalf of the ReSPOND Consortium
YR 2024
UL http://www.ajnr.org/content/45/9/1299.abstract
AB BACKGROUND AND PURPOSE: Understanding sex-based differences in patients with glioblastoma is necessary for accurate personalized treatment planning to improve patient outcomes. Our purpose was to investigate sex-specific differences in molecular, clinical, and radiologic tumor parameters, as well as survival outcomes in patients with glioblastoma, isocitrate dehydrogenase-1 wild-type (IDH1-WT), grade 4.MATERIALS AND METHODS: Retrospective data of 1832 patients with glioblastoma, IDH1-WT with comprehensive information on tumor parameters was acquired from the Radiomics Signatures for Precision Oncology in Glioblastoma consortium. Data imputation was performed for missing values. Sex-based differences in tumor parameters, such as age, molecular parameters, preoperative Karnofsky performance score (KPS), tumor volumes, epicenter, and laterality were assessed through nonparametric tests. Spatial atlases were generated by using preoperative MRI maps to visualize tumor characteristics. Survival time analysis was performed through log-rank tests and Cox proportional hazard analyses.RESULTS: Glioblastoma was diagnosed at a median age of 64 years in women compared with 61.9 years in men (false discovery rate [FDR] = 0.003). Men had a higher KPS (above 80) as compared with women (60.4% women versus 69.7% men, FDR = 0.044). Women had lower tumor volumes in enhancing (16.7 cm3 versus 20.6 cm3 in men, FDR = 0.001), necrotic core (6.18 cm3 versus 7.76 cm3 in men, FDR = 0.001), and edema regions (46.9 cm3 versus 59.2 cm3 in men, FDR = 0.0001). The right temporal region was the most common tumor epicenter in the overall population. Right as well as left temporal lobes were more frequently involved in men. There were no sex-specific differences in survival outcomes and mortality ratios. Higher age, unmethylated O6-methylguanine-DNA-methyltransferase promoter and undergoing subtotal resection increased the mortality risk in both men and women.CONCLUSIONS: Our study demonstrates significant sex-based differences in clinical and radiologic tumor parameters of patients with glioblastoma. Sex is not an independent prognostic factor for survival outcomes and the tumor parameters influencing patient outcomes are identical for men and women.EORextent of resectionFDRfalse discovery rateGTRgross total resectionIDH1-WTisocitrate dehydrogenase-1 wild-typeKPSKarnofsky performance scoreMGMTpO6-methylguanine-DNA-methyltransferase promoterMICEMultiple Imputation by Chained EquationsSTRsubtotal resectionUSUnited StatesWHOWorld Health Organization